严琨，博士、副教授，武汉大学化学与分子科学学院副教授，主要研究对象：无机化学, 化学生物学

基本情况

教育与研究经历

1996-2000 理学学士，武汉大学化学与分子科学学院

2000-2003 理学硕士，武汉大学化学与分子科学学院，有机化学专业，导师吴成泰教授

2003-2007 哲学博士，香港大学化学系，化学生物学专业，导师支志明院士

2007-2008 博士后，香港大学化学系, 支志明院士课题组

2009-2011 博士后，美国约翰霍普金斯大学医学院放射学系，Prof. Jinyuan Zhou课题组

2011-2012 博士后，美国约翰霍普金斯大学医学院Bayview Proteomics Center，Prof. Jennifer Van Eyk课题组

2012.4-至今副教授, 武汉大学化学与分子科学学院

主授课程

主讲本科生必修课《无机化学》、《工程化学》；通识课《生物无机化学》

主讲研究生必修课《生物无机化学》、《无机化学前沿》（部分）

主要研究领域与项目

研究领域

过渡金属配位化合物的合成、生物活性及机理

蛋白质组学在药物开发和疾病诊断中的应用

核磁共振分子成像、磁性/光学探针肿瘤诊断、多模式影像指导下的肿瘤治疗

科研项目

.国家自然科学基金(21401144)

2.湖北省自然科学基金（2013CFB236）

主要学术成果

1. Yan, Kun; Fu, Zongming; Yang, Chen; Zhang, Kai; Jiang, Shenshan; Lee, 越南盾Hoon; Heo, Hye-Young; Zhang, Yi; Cole, Robert N.; Van Eyk, Jennifer E.; Zhou, Jinyuan*. “Assessing 酰胺 Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the Rat Brain Using Proteomic Analysis” 摩尔 Imaging Biol. 2015, DOI: 10.1007/s11307-015-0828-6

2. Lin, 鸢尾属 Wing-Shan; Lok, Chun-Nam; Yan, Kun; Che, Chi-Ming*. “A silver complex of N,N''''''''-disubstituted cyclic 硫脲 as an anti-inflammatory inhibitor of IκB kinase” Chem. Commun. 2013, 49, 3297-3299.

3. Siu, Fung-Ming†; Lin, 鸢尾属 Wing-Shan†; Yan, Kun†; Lok, Chun-Nam; Low, Kam-Hung; Leung, Thomas Yun-Chung; Lam, Tin-Lun; Che, Chi-Ming*. “Anticancer Dirhodium(II) Carboxylates as Potent Inhibitors of Ubiquitin-Proteasome System” Chemical Science 2012, 3, 1785-1793. (Back Cover, †Equal Contributions)

4. Zhou, Jinyuan*; Yan, Kun; Zhu, He. “A Simple Model for Understanding the Origin of the 酰胺 Proton Transfer MRI Signal in Tissue”, APPL Magn. Reson 2012, 42, 393-402.

5. Wang, Silun; Chen, Yifei; Lal, Bachchu, 福特汽车公司, Eric; Tryggestad, Erik; Armour, Michael; Yan, Kun; Laterra, John; Zhou, Jinyuan*. “Evaluation of Radiation Necrosis and Malignant Glioma in Rat Models Using Diffusion Tensor MR Imaging”, J Neurooncol. 2012, 107, 51-60.

6. Zhou, Jinyuan*; Tryggestad, Erik; Wen, Zhibo; Lal, Bachchu; Zhou, Tingting; Grossman, Rachel; Wang, Silun; Yan, Kun; Fu, De-Xue; 福特汽车公司, Eric; Tyler, Betty; Blakeley, Jaishri; Laterra, John; van Zijl, Peter C.M. “Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides”, Nature Medicine 2011, 17, 130-134.

7. Yan, Kun; Lok, Chun-Nam; Bierla, Katarzyna; Che, Chi-Ming*. “Gold(I) complex of N,N’-disubstituted cyclic 硫脲 with in vitro and in vivo anti-cancer properties - potent tight-binding inhibition of thioredoxin reductase”, Chem. Commun. 2010, 46, 7691–7693. (Inside Cover)

8. Zhang, Zhi; Guo, Qian-ni; Lu, Yun-guo; Jia, Tao; Yan, Kun*; Li, Zao-ying*. “Interaction between novel porphyrin-dextran nanoparticles and human serum albumin”, J. Porphyrins Phthalocyanines 2010, 14, 264–270.

9. Zhang, Zhi; He, Rui; Yan, Kun; Guo, Qian-ni; Lu, Yun-guo; Wang, Xu-xia; Lei, Hao; Li, Zao-ying*. “Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent”, Bioorg. Med. Chem. Lett. 2009, 19, 6675-6678.

10. Siu, Fung-Ming; Ma, Dik-Lung; Cheung, Yee-Wai; Lok; Chun-Nam, Yan, Kun; Yang, zhiqi; Yang, Mengsu; Xu, SongXiao; Ko, Ben Chi-Bun; He, Qing-Yu; Che, Chi-Ming*. “Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondriamediated apoptotic pathways”, Proteomics 2008, 8, 3105–3117

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