更新时间：2024-09-21 17:08
徐军伟，1979年11月生，博士，昆明理工大学生命科学与技术学院，教授。
2004年9月- 2009年9月：就读于华东理工大学生物反应器工程国家重点实验室，生物化工专业，获得工学博士学位。
2001年9月- 2004年7月：就读于青岛科技大学化学工程学院，生物化工专业，获得硕士学位。
1997年9月- 2001年7月：就读于河南大学生物系，发酵工程专业，获得学士。
1979年11月生，博士，昆明理工大学生命科学与技术学院，教授。
2009年9月- 2011年10月：于上海交通大学微生物代谢国家重点实验室从事博士后研究，主要从事高等真菌次级代谢产物的代谢工程研究。
2004年9月- 2009年9月：就读于华东理工大学生物反应器工程国家重点实验室，生物化工专业，获得工学博士学位。
2001年9月- 2004年7月：就读于青岛科技大学化学工程学院，生物化工专业，获得硕士学位。
1997年9月- 2001年7月：就读于河南大学生物系，发酵工程专业，获得学士。
学术兼职
担任《Biotechnology \u0026 生物工程学》,《Bioresource Technology》,《Microbial Cell Factories》, 《Biochemical Engineering Journal》,《Process Biochemistry》, 《Bioprocess and Biosystems Engineering》,《Biotechnology and Applied Biochemistry》, 《Applied Biochemistry and Biotechnology》, 《Fungal Biology》,《Pharmaceutical 生物学》等10多本SCI期刊的特邀审稿人。
应用微生物，生物技术，生物制药，微生物代谢工程。
利用云南省微生物资源的优势，筛选生产生物活性物质的药用真菌。建立微生物深层培养的方法，实现活性物质生物反应器规模的大量生产。结合基因组学和功能基因组学技术研究生物活性物质的合成调控机制，并以此为基础改造微生物的代谢途径，实现活性物质代谢流量的最大化。
目前以高等药用真菌灵芝为研究对象，通过基因工程和代谢工程的方法解析生物活性物质灵芝酸（抗癌等功能）和灵芝多糖（增强免疫力等功能）的生物合成调控机制，构建高产工程菌株并实现其规模化生产。
贵州省科技进步一等奖（排名第3），伍达观先进教师奖，红云园丁优秀教师奖。
承担科研项目情况
目前主持国家自然科学基金《灵芝中灵芝酸生物合成相关P450基因的鉴定与功能研究》、《灵芝细胞菌丝形态对抗癌物质灵芝酸发酵过程的调控及其影响机制》两项，云南省科技厅项目一项，2012年云南省高层次引进人才资助项目一项
代表性论文和专著（* 通讯作者）
1.De-Huai Zhang, Lu-Xi Jiang, Na Li, Xuya Yu, peng Zhao, Tao Li, Jun-Wei Xu*(2017) Overexpression of the squalene epoxidase gene alone and in combination with the 3-hydroxy-3-甲基glutaryl coenzyme A gene increases ganoderic acid production inGanoderma lingzhi. Journal of Agricultural and Food Chemistry, 65: 4683-4690
2.De-Huai Zhang,Na Li,Xuya Yu,Peng Zhao,Tao Li, Jun-Wei Xu*(2017) Overexpression of the homologous 羊毛甾醇 synthase gene in ganoderic acid biosynthesis in 灵芝属 lingzhi. Phyto化学, 134: 46-53
3. Huan-Jun Li, Yi-Long He, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Na Li, Jun-Wei Xu*(2016) Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. Journal of Biotechnology, 227: 35-40
4. Huan-Jun Li, De-Huai Zhang, Tong-Hui Yue, Lu-Xi Jiang, Xuya Yu, peng Zhao, Tao Li, Jun-Wei Xu*(2016) Improved 多糖 production in a submerged culture of Ganoderma lucidum by the heterologous expression of Vitreoscilla hemoglobin gene. Journal of Biotechnology, 217: 132-137
5. Huan-Jun Li, De-Huai Zhang, Li-Liang Han, Xuya Yu, Peng Zhao, Tao Li, Jian-Jiang Zhong, Jun-Wei Xu*(2016) Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition. Bioprocess and Biosystems Engineering, 39: 75-80
6. Jun-Wei Xu*,Jian-Jiang Zhong (2015) Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids. Bioengineered, 6: 357-360
7. Jun-Wei Xu*, Sen-Lin Ji, Huan-Jun Li, Meng-Fei Ren, Yan-Qing Duan, Li-Zhi Dang, Ming-He Mo (2015) Increased 多糖 production and biosynthetic gene expressions in a submerged culture of Ganoderma lucidum by the overexpression of the homologous alpha-phosphoglucomutase gene. Bioprocess and Biosystems Engineering, 38: 399-405
8. Sen-Lin Ji, Rui Liu, Meng-Fei Ren, Huan-Jun Li, Jun-Wei Xu*(2015) Enhanced production of polysaccharide through the overexpression of the homologous UDP glucose pyrophosphorylase gene in a submerged culture of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 17: 435-442
9. Jiang-Sheng Zhou, Sen-Lin Ji, Meng-Fei Ren, Yi-Long He, Xiao-Ran Jing, Jun-Wei Xu*(2014) Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene. Biochemical Engineering Journal, 90: 178-183
10. Xuya Yu, Sen-Lin Ji, Yi-Long He, Meng-Fei Ren, Jun-Wei Xu*(2014) Development of an expression plasmid and its use in genetic manipulation of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher basidiomycetes). International Journal of Medicinal Mushrooms, 16: 161-168
11. Yan-Qing Duan, Zhan-Chang Xing, Jun-Wei Xu*(2013) Screening of a high yield 多糖 strain from ten edible and medicinal fungi and optimization of its culture conditions. Research Journal of Biotechnology, 8:11-15
12. Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2012) Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-甲基glutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum. Applied and Environmental Microbiology, 78: 7968-7976
13. Jun-Wei Xu, Wei Zhao, Yi-Ning Xu, Jian-Jiang Zhong (2012) Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization. Molecular 生物学 Reports, 39: 3603-3610
14. Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2011) Isolation and characterization of a novel Ganoderma lucidum gene that differentially expressed between shaking culture and liquid static culture. Genes \u0026 Genomics, 33: 645-651
15. Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2010) Biotechnological production and application of ganoderic acids. Applied Microbiology and Biotechnology, 87: 457-466
16. Jun-Wei Xu, Yi-Ning Xu, Jian-Jiang Zhong (2010) Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 85: 941-948
Resume
Contact Information：
Name: Jun-Wei Xu
Degree: Ph.D.
Position \u0026 Title: The Professor of Bioengineering
Education:
2009.9 -2011.10, Post-doctor, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong
University.
2004.9-2009.9, Ph.D., Biochemical Engineering, The State Key Laboratory of Bioreactor Engineering,
East China University of Science and Technology.
2001.9-2004.7, M.S., Biochemical Engineering, Qingdao University of Science and Technology.
1997. 9-2001.7, B.S., Fermentation Engineering, Henan University.
Research Interests:
1. Applied Microbiology
2. Biotechnology
3. Microbial metabolic engineering
Research Profile:
1. Screening of new strains with industrial potential for producing bioactive compounds.
2. Submerged fermentation of higher fungi for production of valuable bioactive compounds in bioreactor.
3. Elucidation of the biosynthesis and regulatory mechanism of bioactive compounds in higher fungi by
comparative genomic analysis, proteomic analysis and metabolic flux analysis.
4. Metabolic engineering of bioactive compounds-producing higher fungi.
Research Project:
Two projects from National Natural Science Foundation of China (NSFC) and one project from Yunnan Provincial Science and Technology Department.
Awards:
1st-Class Award for the Advancement of Science and Technology by Guizhou Province (2016)
SCI-Journal Reviewer:
Bioresource Technology; Biotechnology \u0026 生物工程学; Microbial Cell Factories; Biochemical Engineering Journal; Process Biochemistry; Bioprocess and Biosystems Engineering; Biotechnology and Applied Biochemistry; Applied Biochemistry and Biotechnology; Fungal 生物学; Pharmaceutical Biology; Interdisciplinary Sciences–Computational Life Sciences