更新时间：2024-09-20 19:03
江中兴，博士、教授、武汉大学药学院博士生导师、楚天学者特聘教授。
在研项目： “基于单一分子量聚乙二醇的生物材料的设计、合成及其在生物大分子药物研发中的应用”，国家自然科学基金面上项目，批准号21572168，65万元，2016年-2019年； “F-19 MRI 可视化5-FU 传输载体的合成与应用研究”，国家自然科学基金面上项目，批准号21372181，78万元，2014年-2017年； “含树枝状大分子显影材料的制备与应用”，东华大学纤维材料改性国家重点实验室开放课题，10万元，2015年-2017年； “盐霉素的结构改造及活性研究”，中科院天然产物有机合成化学重点实验室开放课题，3万元，2015年-2016年
在SCI期刊上发表文章30余篇，文章被引用600余次，H-index\u003e14；申请美国专利4项，中国专利奖4项，其中2项美国专利及1项中国专利已经获的授权；任Journal of Biomolecular Research \u0026 Therapeutics编委，受邀为Bioconjugate 化学，Journal of Organic Chemistry，Journal of 萤石 Chemistry等10余个英文学术期刊审稿人，相关研究成果被Faculty of 1000, F-blog, RSC Advances等多次评述；主持国家自然科学基金面上项目等多个研究项目，指导多个国家级大学生创新创业项目.
1995年9月至1999年7月 西南大学化学化工学院获学士
1999年8月至2004年7月 中科院上海有机化学研究所获博士学位
2004年8月至2007年4月 犹他大学药学院博士后
2007年4月至2008年8月 美国印第安纳大学医学院博士后
2008年8月至2011年10月 马里兰大学药学院研究助理教授
2011年10月至今 武汉大学药学院教授
药物化学，有机化学，分子影像学，新型生物材料，药物的可视化传输与缓释
在SCI期刊上发表文章31篇，文章被引用550余次，H-index\u003e12；申请美国专利4项，中国专利奖3项，其中3项美国专利已经获批；任 Journal of Biomolecular Research \u0026 Therapeutics 编委，相关研究成果被Faculty of 1000, F-blog, RSC Advances等多次评述。
1. Yu Y.B., Jiang Z.-X. “Highly fluorinated ß-amino acids and methods of making and using same”美国专利号 US 8,052,961B2
2. Yu Y.B., Jiang Z.-X. “Highly fluorinated oils and surfactants and methods of making and using same”美国专利号 US 8,252,778B2
3. Yu Y.B., Jiang Z.-X., Xiao N. “Protected enantiopure trifluorothreonines and methods of making and using same”申请号 PCT/US2007/078552，国际公开号 WO2008034095
4. Yu Y.B., Jiang Z.-X.“Conjugates of F MR imaging tracers for use in multi-chromic MRI imaging”申请号 PCT/US2009/63381
5. 江中兴，张华，李学飞，李昱“一种单一分子量聚乙二醇及其衍生物的合成方法” CN201310710498.6
6. 江中兴，李学飞，李昱，夏桂全“一种新型大环环硫酸及其制备方法与运用”CN201310656494.4
7. 江中兴，余伟江，薄少伟“一种树枝状大分子氟-19磁共振显影剂及其制备方法和应用” CN20150037920.5
Jiang Z.-X., Li X., Qing F.-L. “A green 化学 strategy: fluorous catalysis” Book chapter in “Bridging Heterogeneous and Homogenous Catalysis” Edited by Li C., Liu Y. Wiley-VCH，p253-282, 2014.
1.Yu W., Yang Y., Bo S., Li Y., Chen S., Yang Z., Zheng X., Jiang Z.-X.*, Zhou X. “The 设计 and Synthesis of Fluorinated Dendrimers for Highly Sensitive F MR” J. Org. Chem. 2015, in print (IF 4.64).
2.Zhang H., Li X., Shi Q., Li Y., Xia G., Chen L., Yang Z., Jiang Z.-X.* “Highly efficient synthesis of monodisperse poly(乙烯 glycols) and derivatives through macrocyclization of oligo(ethylene glycols)” Angew. Chem. Int. Ed. 2015, DOI: 10.1002/anie.201410309 (IF 11.34).
3.Taraban M. B., Li Y., Yue F., Jouravleva E. V., Anisimov M. A., Jiang Z.-X., Yu Y. B.* “Conformational transition of a non-associative fluorinated amphiphile in aqueous solution” RSC Adv. 2014, 4(97), 54565-54575.
4.Xia G., Li Y., Li Y., Li X., Zhang H., Yu Y. B., Jiang Z.-X.* “Optimize the separation of fluorinated amphiles using high-performance liquid chromatography” J. Fluorine Chem. 2014, 165, 39-42.
5.Li Y., Guo Q., Li X., Zhang H., Yu F., Yu W., Xia G., Fu M., Yang Z., Jiang Z. -X.* “Fluorous synthesis of mono-dispersed poly(乙烯 glycols)” Tetrahedron Lett. 2014, 55，2110-2113.
6.Jiang Z.-X., Zhi S., Zhang W.* “Recent progress on fluorous synthesis of biologically interesting compounds” 摩尔 Divers. 2014, 18, 203-218.
7.Li Y., Thapa B., Zhang H., Li X., Yu F., Jeong E.-K., Yang Z., Jiang Z.-X.* “Synthesis of gemini surfactants with twelve symmetric fluorine atoms and one singlet F MR signal as novel F MRI agents” Tetrahedron 2013, 69, 9586-9590.
8.Zhang H., Li Y., Jiang Z.-X.* “Fluorine is flourishing in pharmaceuticals” J. Bio摩尔 Res. Thera. 2012, 1:e107.
9.Yu Y. B.,* Jiang Z.-X. “Prospect of F MRI-guided drug delivery” J. Pharm. Drug Deliv. Res. 2012, 1, 1
10.Jiang Z.-X., Feng Y., Yu Y.B.* “Fluorinated paramagnetic chelates as potential multi-chromic F tracer agents” Chem. Comm. 2011, 47, 7233-7235.
11.Jiang Z.-X., Yu Y.B.* “Fluorous mixture synthesis of asymmetric dendrimers” J. Org. Chem., 2010, 75, 2044–2049.
12.He R., Yu Z., He Y., Zeng L.-F., Xu J., Wu L., Gunawan A. M., Wang L., Jiang Z.-X., Zhang Z.-Y.* "Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor" ChemMedChem, 2010, 5, 2051-2056.
13.Zhang X., He Y., Liu S., Yu Z., Jiang Z.-X., Yang Z., 越南盾 Y., Nabinger S.C., Wu L., Gunawan A.M., Wang L., Chan R.J., Zhang Z.-Y.* “Salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) ” J. Med. Chem., 2010, 53, 2482–2493.
14.Zhang X.,* Fan S., He C.-Y., Wan X., Min Q.-Q., Yang J., Jiang Z.-X. “Pd(OAc) Catalyzed olefination of highly electron-deficient perfluoroarenes” J. Am. Chem. Soc., 2010, 132, 4506–4507.
15.Jiang Z.-X., Liu X., Jeong E.-K., Yu Y.B.* “Symmetry-guided 设计 and fluorous synthesis of a stable and rapidly excreted imaging tracer for F MRI” Angew. Chem. Int. Ed. 2009, 48, 4755-4758.
16.Jiang Z.-X., Zhang Z.-Y.* “Targeting PTPs with small molecule inhibitors in cancer treatment” Cancer and Metastasis Reviews. 2008, 27, 263-272.
17.Jiang Z.-X., Yu Y.B.* “The 设计 and synthesis of highly branched and spherically symmetric fluorinated macrocyclic chelators” Synthesis. 2008, 2, 215-220.
18.Liu S., Zhou B., Yang H., He Y., Jiang Z.-X., Kumar S., Wu, L., Zhang Z.-Y.* “Aryl vinyl sulfones and sulfonates as active site-directed and mechanism-based probes for protein tyrosine phosphatases” J. Am. Chem. Soc. 2008, 130, 8251-8260.
19.Jiang Z.-X., Yu Y.B.* “The 设计 and synthesis of highly branched and spherically symmetric fluorinated oils and amphiles” Tetrahedron. 2007, 63, 3982-3988.
20.Jiang Z.-X., Yu Y.B.* “The synthesis of a geminally perfluoro-tert-butylated b-amino acid and its protected forms as a potential pharmacokinetic modulator and reporter for peptide-based pharmaceuticals” J. Org. Chem. 2007, 72, 1464-1467.
21.Wang B.-L., Jiang Z.-X., You Z.-W., Qing F.-L.* “Total synthesis of trifluoromethylated analogs of macrosphelide A” Tetrahedron. 2007, 63, 12671-12680.
22.Xiao N., Jiang Z.-X., Yu Y.B.* “Enantioselective synthesis of (2R, 3S)- and (2S, 3R)-4,4,4- trifluoro-N-Fmoc-O-tert-butyl-threonine and their racemization-free incorporation into oligopeptides via solid-phase synthesis” Biopolymers (Peptide Science). 2007, 88, 781-796.
23.You Z.-W., Jiang Z.-X., Wang B.-L., Qing F.-L.* “An efficient and general route to gem-difluoromethylenated a,b-unsaturated d-lactones: high enantioselective synthesis of gem- difluoromethylenated goniothalamins” J. Org. Chem. 2006, 71, 7261-7267.
24.Wang B.-L, Yu F., Qiu X.-L., Jiang Z.-X, Qing F.-L.* “Synthesis of trifluoromethylated analogues of b-L-fucofuranose and b-L-4, 6-dideoxyxylohexopyranose” J. Fluorine Chem. 2006, 127, 580-587
25.Jiang Z.-X., Liu X.-P., Qiu X.-L., Qing F.-L.* “Asymmetric synthesis of both enantiomers of syn-3-(trifluoromethyl)cysteine derivatives” J. Fluorine Chem. 2005, 126, 499-505.
26.Jiang Z.-X., Qing F.-L.* “Regioselective and stereoselective nucleophilic ring opening of trifluoromethylated cyclic sulfates: asymmetric synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine” J. Org. Chem. 2004, 69, 5486-5489.
27.Jiang Z.-X., Qin Y.-Y., Qing F.-L.* “Asymmetric synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid” J. Org. Chem. 2003, 68, 7544-7547.
28.Jiang Z.-X., Qing F.-L.* “Sodium carbonate as carbon dioxide source for the synthesis of cyclic carbonates containing the trifluoromethyl group” J. Fluorine Chem. 2003, 123, 57-60.
29.Qing F.-L.,* Jiang Z.-X. “Synthesis of trifluoromethylated b-and g-lactones through the Palladiumcatalyzed cyclocarbonylation” J. Fluorine Chem. 2002, 114, 177-180.
30.Jiang Z.-X., Qing F.-L.* “Palladium-catalyzed cyclocarbonylation of trifluoromethyl propargylic alcohols producing 3-trifluoromethyl-2(5H)-furanones (g-lactones)” Tetrahedron Lett. 2001, 42, 小行星90519053.
31.Qing F.-L.,* Jiang Z.-X. “Palladium-catalyzed cyclocarbonylation of (Z)-3-iodo-3- trifluoromethyl allylic alcohols producing 3-trifluoromethyl-2(5H)-furanones (g-lactones)” Tetrahedron Lett. 2001, 42, 5933-5935.