王畅 :苏州大学副教授

更新时间:2024-09-21 15:08

苏州大学副教授,主要从事电离辐射损伤代谢、放射生物剂量估计和电离辐射防护药物方面的研究。和他人合作在国内外学术期刊发表多篇方向性论文。

人物经历

1995年考入陕西师范大学化学系,1999年毕业获得理学学士。同年九月考入该校化学系,从事化学发光和微流控芯片的研究,于2002年获得理学硕士学位。同年九月开始在中科院大连化学物理研究所攻读博士学位,在导师许国旺研究员的指导下从事代谢组学研究——电喷雾质谱和液相色谱-质谱联用技术的磷脂分析方法研究及其在磷脂代谢中的应用。于2006年3月于中国科学院大连化学物理研究所获得理学博士学位。2006年4月起至今于苏州大学工作,从事电离辐射损伤代谢、放射生物剂量估计和电离辐射防护药物的研究。

研究方向

电离辐射损伤代谢研究、放射生物剂量估计研究、电离辐射防护药物研究

主要贡献

已在国内外期刊和会议上发表文章如下:

1 Chang Wang, Sigang Xie, Jun Yang, Qing Yang, Guowang Xu. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap 质量 Spectrometry. Anal. Chim.Acta, 2004, 525(1):1-10

2 Chang Wang, Hongwei Kong, Yufeng Guan, Jun Yang, Jianren Gu, Shengli Yang, Guowang Xu. Plasma Phospholipid Metabolic Profiling and Biomarkers of Type 2 糖尿病 Mellitus Based on High Performance Liquid Chromatography/Electrospray 质量 Spectrometry and Multivariate Statistical Analysis. Anal. Chem., 2005,77:4108-4116

3 Chang Wang, Jun Yang, Peng Gao, Xin Lu,Guowang Xu. Identification of phospholipid structures in human blood by direct-injection quadrupole-linear ion-trap 质量 spectrometry. Rapid Commun. Mass Spectrom. 2005, 19: 2443–2453

4 Chang Wang, Yun Yang, Jihua Nie. Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–质量 spectrometry technique. J. Biomed.Chromatogr,2009, 23: 1079-1085.

5 Lewen Jia, Chang Wang, Hongwei Kong, Jun Yang, Fanglou Li, Shen Lv, Guowang Xu. Effect of 人民军MSHA Vaccine on Plasma Phospholipids Metabolic Profiling and the Ratio of Th2/Th1 Cells within Immune Organ of Mouse IgA Nephropathy, J. Pharm. Bioanal., 2007,4: 646-654

6 Lewen Jia, Chang Wang, Sumin Zhao, Xin Lu, Guowang Xu. Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-质量 spectrometry. J. Chromatogr. B, 2007, 860 (1) : 134-140

7 Lewen Jia, Chang Wang, Hongwei Kong , Zongwei Cai, Guowang Xu. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy,Metabolomics, 2006, 2(2),95-104

8 Qiurong Li, Li Tan, Chang Wang, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts. Eur. J. Nutrition, 2006, 45(3):144-151

9 Qiurong Li, Meng Wang, Li Tan, Chang Wang, Qian Shi, Ning Li, Yousheng Li, Guowang Xu, and Jieshou Li. Docosahexaenoic acid changes lipid composition and interleukin-2 捕手 signaling in membrane rafts. J. Lipid Res. 2005, 46: 1904-1913.

10 Jun Yang, Xinjie Zhao, Xiaoli Liu, Chang Wang, Peng Gao, Jiangshan Wang, Lanjuan Li, Jianren Gu, Shengli Yang, Guowang Xu. High Performance Liquid Chromatography-质量 Spectrometry for Metabnomics: Potential Biomarkers for Acute Determination in Liver 函数 of Chronic Hepatitis B. J.Proteome Res., 2006, 5:554-561.

11 王畅,谢四刚,杨军,杨青,许国旺 液相色谱-线性离子阱质谱法鉴定人血中磷脂乙醇胺类分子组成.色谱,2004,22(4):316-320.

12 王畅,郑育芳,熊建辉,翁前锋 Ca2 + 与乳清蛋白结合的亲和毛细管电泳研究. 化学学报, 2004,62(3):279-282.

13 王畅,吕家根,章竹君 微透析采样荧光法研究6-硫鸟嘌呤与蛋白结合作用。化学学报, 2002,60(9):1672-1676

14 Guowang Xu,Chang Wang. Structural Identification of Human Blood Phospholipids Using Liquid Chromatography/Quadrupole-linear ion trap 质量 Spectrometry. The third Sino-Japanese Joint Seminar on Separation Sciences. 2004, 20-22.

15 Guowang Xu, Jun Yang, Chang Wang, Hongwei Kong, Xinjie Zhao, Kailong Yuan, Jiangshan Wang, Xin Lu,Metabonomics applications in disease biomarker discovery and safety and efficacy assessments of traditional chinese medicines based on GCX乔治十字勋章TOF MS and UPLC-Q-TOFMSn ,Ninth International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-9), York (United Kingdom), February 8th-10th, 2006.

16 Guowang Xu, Chang Wang, Jun Yang, Xinjie Zhao, Jiangshan Wang, Hongwei Kong, Kailong Yuan, Yuan Wang, Chenfei Ma, Xin Lu, Applications of GCxGC-TOF MS and UPLC/Q-TOF MSn in Metabonomics: Disease Biomarker Discovery and Safety Assessment and Quality Control of Traditional Chinese Medicines, 16th Annual Conference on Chromatography of Japan, Gifu, 2005.11

17 著作:参与撰写《代谢组学——方法与应用》,科学出版社(ISBN: 978-7-03-021528-4), 2008年,第8章:类脂和类脂组学(pp161-194)

科研项目:

脂类组学方法筛选急性辐射损伤生物剂量估计指标(批准号:31000385),国家自然科学基金,项目负责人。

氨基酸靶标分析用于急性辐射损伤生物剂量估计的研究,江苏省高校自然科学研究项目(批准号:10KJB310012)

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