秦莹莹(山东大学附属生殖医院工作人员)

秦莹莹，女，1977年11月出生，枣庄市人，山东大学附属生殖医院党委书记、教授。主任医师、博士生导师。山东省第十四届人民代表大会代表。

2019年受邀担任第23届IFFS世界大会摘要评审主席。2019年秦莹莹入选山东大学国际合作联络教授。先后培养博士后、博士及硕士研究生20余名。她的研究方向是早发性卵巢功能不全POI临床及致病机制研究。受邀在日本生殖医学年会、国际生殖医学联盟（IFFS）年会作专题报告。

人物经历

1995.9 -- 2000.7 青岛大学医学院临床医学医学学士

2002.9 -- 2007.7 山东大学妇产科学医学博士学位

2007.11 -- 2010.5 山东大学

2007.7 -- 至今山东大学生殖医学研究中心

2002.2 -- 2002.8 滕州市中心人民医院

科研成果

秦莹莹教授长期致力于提高女性生殖健康与防治出生缺陷的基础与临床研究，取得了系列原创性成果，为临床精准诊疗提供科学依据。她揭示了早发性卵巢功能不全（POI）的致病新机制，建立了中国女性卵巢储备评估体系，创新了卵泡体内、体外激活干预策略，并开展了高水平多中心临床研究，提供了胚胎植入前非整倍体检测临床应用的循证医学I级证据。她所在的团队发现了一系列POF致病新基因NOBOX、CSB-PGBD3、MSH5、BRCA2等，目前国际上命名的卵巢早衰基因共14个，秦莹莹教授所在的山大生殖团队发现了4个，充分体现了中国学者的贡献。

代表论著

作为首席专家，在New Engl J Med、Am J Hum Genet、Hum Reprod Update、Trends Endocrinol Metab等国际主流杂志发表SCI论文40余篇，累计影响因子183。

1. Ting Guo#; Ye Zheng#; Guangyu Li; Shidou Zhao; Jinlong Ma;Yingying Qin*; Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency.,Fertil Steril, 2020, 113(4): 845-852.

2. Xiaoyan Wang; Xinyue Zhang; Yujie Dang; Duan Li; Gang Lu; Wai-Yee Chan; Peter C. K. Leung; Shidou Zhao;Yingying Qin*; Zi-Jiang Chen; Long noncoding 核糖核酸 HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and 脱氧核糖核酸 damage repair via YB1.,Nucleic Acids Res, 2020, 48(8): 4480-4491.

3. Hanni Ke; Jingmei Hu; Lijuan Zhao; Lingling Ding; Xue Jiao*;Yingying Qin*; Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection.,Thyroid, 2020, 30(4): 588-597.

4. Yajuan Yang; Ting Guo; Ran Liu; Hanni Ke; Weiwei Xu; Shidou Zhao*;Yingying Qin*; FANCL gene mutations in premature ovarian insufficiency.,Hum Mutat, 2020, 41(5): 1033-1041.

5.Yingying Qin; Feng Zhang; Zi-Jiang Chen*; BRCA2 in Ovarian Development and Function,N Engl J Med, 2019, 380(11): 1086-1086.

6. Tuo Zhang#; Xinhua Du#; Lihua Zhao#; Meina He; Lin Lin; Chuanhui Guo; Xinran Zhang; Jun Han; Hao Yan; Kun Huang; Guanghong Sun; Lei Yan; Bo Zhou; Guoliang Xia;Yingying Qin*; Chao Wang*; SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription.,FASEB J, 2019, 33(12): 14703-14716.

7. Hongli Liu#; Ting Guo#; Zheng Gong; Yongze Yu; Yingxin Zhang; Shidou Zhao*;Yingying Qin*; Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency,摩尔 Cell Endocrinol, 2019, 492: 0-UNSP 110446.

8. Yang Zhou#; Yan Qin#;Yingying Qin#; Binyang Xu; Ting Guo; Hanni Ke; Min Chen; Lianjun Zhang; Feng Han; Yaqiong Li; Min Chen; Axel Behrens; Yaqing Wang; Zhiheng Xu*; Zi-Jiang Chen*; Fei Gao*; Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans.,PLoS 獛属, 2018, 14(8): 0-e1007463.

9. Yujie Dang; Xiaoyan Wang; Yajing Hao; Xinyue Zhang; Shidou Zhao; Jinlong Ma;Yingying Qin*; Zi-Jiang Chen*; MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6,Cell 死亡 Dis, 2018, 9(2).

10. Xue Jiao; Hanni Ke;Yingying Qin*; Zi-Jiang Chen*; Molecular Genetics of Premature Ovarian Insufficiency,Trends Endocrinol Metab, 2018, 29(11): 795-807.

11. Ting Guo; Shidou Zhao; Shigang Zhao; Min Chen; Guangyu Li; Xue Jiao; Zhao Wang; Yueran Zhao;Yingying Qin*; Fei Gao*; Zi-jiang Chen*; Mutationsin MSH5 in Primary Ovarian Insufficiency.,Hum 摩尔 Genet, 2017, 26(8): 1452-1457.

12. Xiaoyun Dou#; Ting Guo#; Guangyu Li; LiGuang Zhou;Yingying Qin*; Zi-Jiang Chen; Minichromosome maintenance complex component 8 mutations cause primary ovarian insufficiency,Fertil Steril, 2016, 106(6): 1485-1489.

13. Linlin Cui#;Yingying Qin#; Xuan Gao; Jun Lu; Ling Geng; Lingling Ding; Zhongyu Qu; Xiruo Zhang; Zi-Jiang Chen*; Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause.,Fertil Steril, 2016, 105(2): 481-485.

14.Yingying Qin; Xue Jiao; Joe leigh Simpson; Zi-Jiang Chen*; Genetics of primary ovarian insufficiency: new developments and opportunities,Hum Reprod Update, 2015, 21(6): 787-808.

15.Yingying Qin#*; Ting Guo#; Guangyu Li; Tie-Shan Tang; Shidou Zhao; Xue Jiao; Juanjuan Gong; Fei Gao; Caixia Guo; Joe Leigh Simpson; Zi-Jiang Chen*; CSB-PGBD3 Mutations Cause Premature Ovarian Failure,PLoS 獛属, 2015, 11(7): e1005419.

16.Yingying Qin#; Xue Jiao#; Raymond Dalgleish; Svetlana Vujovic; Jin Li; Joe Leigh Simpson; Farook Al-Azzawi*; Zi-Jiang Chen*; Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure,Fertil Steril, 2014, 101(4): 1104-1109.

17.Yingying Qin; Svetlana Vujovic; Guangyu Li; Jin Li; Raymond Dalgleish; Joe Leigh Simpson; Maja Ivanisevic; Miomira Ivovic; Milina Tancic; Farook Al Azzawi*; Zi-Jiang Chen*; Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women,Maturitas, 2014, 77(1): 64-67.

18.Yingying Qin; Han Zhao; Jianfeng Xu; Yongyong Shi; Zhiqiang Li; Jie Qiao; Jiayin Liu; Chunrong Qin; Chune Ren; Jie Li; Shiling Chen; Yunxia Cao; China POF Study Group; Joe Leigh Simpson; Zi-Jiang Chen*; Association of 8q22.3 locus in Chinese Han with idiopathic premature ovarian failure (POF),Human Molecular Genetics, 2012, 21(2): 430-436.

19. Yujie Dang#;Yingying Qin#; Rong Tang; Yulan Mu; Guangyu Li; Mingdi Xia; Zi-Jiang Chen*; Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities,Fertil Steril, 2012, 97(2): 391-394.

20.Yingying Qin; Youngsok Choi; Han Zhao; Joe Leigh Simpson; Zi-Jiang Chen; Aleksandar Rajkovic*; NOBOX homeobox mutation causes premature ovarian failure,Am J Hum 獛属, 2007, 81(3): 576-581.