更新时间：2024-09-21 03:31
韩晓，博士，南京医科大学教授，博士生导师，江苏省人类功能基因组学重点实验室主任，南京医科大学生物学一级学科博士点带头人。
韩晓，男，博士，特聘教授，博士生导师，江苏省人类功能基因组学重点实验室主任。1986年毕业于武汉同济医科大学六年制医学本科，同年考取同济医科大学分子病毒学与免疫学专业硕士研究生，硕士毕业后留校任教。于1991年公派赴德国维尔茨堡大学攻读生物免疫与病毒学博士学位，1994年获博士学位后在德国明斯特大学分子医学所从事细胞因子、金属蛋白酶和糖尿病的博士后研究。1996年赴美国洛衫矶City of Hope National Medical Center糖尿病研究中心从事分子免疫学与糖尿病等的研究。曾获美国国际青少年糖尿病研究基金会资助（JDRF），2003年元月回国定居，被南京医科大学聘为教授、江苏省人类功能基因组学重点实验室学科带头人。
2023年6月14日，国家自然科学基金委员会公布2023年度医学科学部基础科学中心和创新研究群体项目专业评审组组成名单，韩晓在列。
糖尿病发病机制。
利用先进的分子生物学和生物化学技术，发现花生四烯酸-前列腺素生成信号转导途径中，12-脂氧化酶的代谢产物12-HETE其有诱导前列腺素合成的关键酶--环加氧酶-2（COX-2）基因转录和表达的作用，而用12-脂氧化酶的抑制剂-咖啡酸类物质，可以抑制12-HETE的合成，从而减弱COX-2基因的转录和表达，进而减少前列腺素的合成。鉴于前列腺素有抑制β-细胞分泌胰岛素的作用，所以，这一新的信号转导通路的发现，有助于进一步揭示1、2型糖尿病对胰岛β-细胞发生功能障碍的机理。发现了基质金属蛋白酶组织抑制因子-1（TIMP-1）对胰岛β-细胞的凋亡具有保护作用，并借助分子生物学和细胞生物学技术，进一步研究了胰岛β-细胞发生凋亡的机理，揭示了核转录因子NF-KB与β-细胞发生凋亡之间的关系，为转基因胰岛移植及1型糖尿病的基因治疗提供了新的新的思路。已在多种国际著名学术期刊上发表学术论文，且在COX-2基因调控的信号转导方面获一项美国专利。
获得省部级奖励1项，获得一项美国专利和二项中国专利奖。获江苏省科技进步二等奖一项（排名第一）；江苏省有突出贡献中青年专家，江苏省“333”突出贡献奖。
1.Wang Y, Lin H, Hao N, Zhu Z, Wang D, Li Y, Chen H, Zhu Y, Han X*. Forkhead box O1 mediates defects in palmitate-induced 胰岛素 granule exocytosis by downregulation of 钙/calmodulin-dependent serine protein kinase expression in INS-1 cells.Diabetologia. 2015 Mar 22. [Epub ahead of print]
2.Qiao N, Xu C, Zhu YX, Cao Y, Liu DC, Han X*. Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells. Cell 死亡 Dis. 2015 Feb 19;6:e1650.
3.Nie J, Liu X, Lilley BN, Zhang H, pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X*, Shi Y*. SAD-A kinase controls islet β-cell size and 函数 as a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62
4.Zhu Y, You W, Wang H, Li Y, Qiao N, Shi Y, Zhang C, Bleich D, Han X*. MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction. 糖尿病 2013 Sep;62(9):3194-206.
5.Nie J, Lilley BN, pan YA, Faruque O, Liu X, Zhang W, Sanes JR, Han X*, Shi Y*. SAD-A Potentiates Glucose-Stimulated 胰岛素 Secretion as a Mediator of 胰高血糖素Like Peptide 1 Response in Pancreatic β Cells. 摩尔 Cell Biol. 2013 Jul;33(13):2527-34.
6.Lin HY, Yin Y, Zhang JX, Xuan H, Zheng Y, Zhan SS, Zhu YX, Han X*, Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal 胰岛素secreting cells using chromatin immunoprecipitation coupled to 脱氧核糖核酸 selection and ligation, Diabetologia. 2012 Oct;55(10):2703-12..
7.Nie J, Sun C, Faruque O, Ye G, Li J, Liang Q, Chang Z, Yang W, Han X*, Shi Y*, Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated 胰岛素 secretion through activation of p21-activated kinase (PAK1) in pancreatic β-cells, J Biol Chem. 2012 Jul 27;287(31):26435-44.
8.Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X*. Aberrant activation of liver X 捕手s impairs pancreatic beta cell 函数 through upregulation of Sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia, 2012 Jun;55(6):1733-44. Epub 2012 Mar 14.6.973
9.Li W, Chen Z, Gong FR, Zong Y, Chen K, Li DM, Yin H, Duan WM, Miao Y, Tao M, Han X*, Xu ZK*. Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway. Eur J Cancer. 2011 Nov; 47(17):2654-64. Epub 2011 Sep 28. 4.944
10.Shu T, Zhu Y, Wang H, Lin Y, Ma Z, Han X*. AGEs Decrease 胰岛素 Synthesis in Pancreatic β-Cell by Repressing Pdx-1 Protein Expression at the Post-Translational Level. PLoS One. 2011 Apr 18;6(4): e18782. 4.351
11.Chen F, Zhu Y, Tang X, Sun Y, Jia W, Sun Y, Han X*. Dynamic Regulation of PDX-1 and FoxO1 Expression by FoxA2 in Dexamethasone-Induced Pancreatic {beta}-cells Dys函数 内分泌学 2011 May;152(5):1779-88. Epub 2011 Mar 8. 4.752
12.Li W, Chen Z, Zong Y, Gong F, Zhu Y, Zhu Y, Lv J, Zhang J, Xie L, Sun Y, Miao Y, Tao M, Han X*, Xu Z*. PP2A inhibitors induceapoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway. Cancer Lett. 2011 May 28;304(2):117-27. Epub 2011 Mar 3. 3.741
13.Shen H, Xu W, Luo W, Zhou L, Yong W, Chen F, Wu C, Chen Q, Han X*. Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell 淋巴瘤 Exp Hematol. 2011 May;39(5):558-69. Epub 2011 Feb 24. 3.106
14.Zhu Y, Shu T, Lin Y, Wang H, Yang J, Shi Y, Han X*. Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells. Biochem Biophys Res Commun. 2011 Jan 7; 404(1):159-65. 2.548
15.Lin Y, Tang X, Zhu Y, Shu T, Han X*. Identification of PARP-1 as one of thetranscription factors binding to the repressor element in the promoter region of COX-2. Arch Biochem Biophys. 2011 Jan 1; 505(1):123-9. 3.046
16.Guo J, Zhu JX, Deng XH, Hu XH, Zhao J, Sun YJ, Han X*. Palmitate-induced inhibition of 胰岛素 gene expression in rat islet β-cells involves the ceramide transport protein. Cell Physiol Biochem. 2010;26(4-5):717-28. 3.563
17.Li W, Xie L, Chen Z, Zhu Y, Sun Y, Miao Y, Xu Z*, Han X*. Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. Cancer Sci. 2010 May;101(5):1226-33. 3.771
18.Guo J, Qian Y, Xi X, Hu X, Zhu J, Han X*. Blockage of 神经酰胺 新陈代谢 exacerbates palmitate inhibition of pro-胰岛素 gene expression in pancreatic beta-cells. 摩尔 Cell Biochem. 2010 May;338(1-2):283-90. 1.896
19.Meng Z, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X*. Forkhead Box O1/Pancreatic and Duodenal Homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology. 2009 Dec; 150(12):5284-93. 4.945
20.Zhou X, Zheng M, Chen F, Zhu Y, Yong W, Lin H, Sun Y, Han X*.Gefitinib inhibits the proliferation of pancreatic cancer cells via cell cycle arrest. Anat Rec (Hoboken). 2009 Aug; 292(8):1122-7. 1.569
21.Zhang XF, Yong W, Lv JH, Zhu YX, Zhang JJ, Chen F, Zhang RH, Yang T, Sun YJ, Han X*. Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dys函数 内分泌学 2009 Sep; 150(9):4065-73. 4.945
22.Xia W, Zhao T, Lv JH, Xu S, Shi J, Wang S, Han X*, Sun YJ*. Celecoxib enhanced the sensitivity of cancer cells to anticancer drugs by inhibition of the expression of P-glycoprotein through a COX-2-independent Manner. J Cell Biochem. 2009 Sep 1;108(1):181-94. 3.54
23.Yin Y, Wang S, Sun Y, Matt Y, Colburn NH, Shu Y*, Han X*. JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells. Biomed Pharmacother. 2009 Jul; 63(6):429-35. 2.198
24.Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X*. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 2009 Jan;52(1):125-35. 6.418
25.Yang X, Lin L, Zhang X, Ji Y, Lv J, Zhu Y, Yin Y, Sun Y, Han X*. Identification of a novel repressor element in the cyclooxygenase-2 promoter and its nuclear binding protein. Clin Exp Pharmacol Physiol. 2008 Oct;35(10):1204-8. 2.04
26.Zhu J, Yong W, Wu X, Yu Y, Lv J, Liu C, Mao X, Zhu Y, Xu K, Han X*, Liu C*. Anti-inflammatory effect of 白藜芦醇 on TNF-alpha-induced MCP-1 expression in adipocytes. Biochem Biophys Res Commun. 2008 May 2; 369(2):471-7. 2.75
27.Ma C, Zhang JJ, Durrin KL. Lv JH, Zhu D, Han X*, and Sun Y*.（2007). The BCL2 少校 breakpoint region (mbr) regulates gene expression. Oncogene 26（18）2649-57 IF 6.440 co-corresponding author
28.Meng Z, Sun J, Ling J, Lv J, Zhu DY, Chen Q, Sun Y* and Han X*. (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islat beta-cell dysfunction. Diabetologia 49(12):2959-68 IF 5.337 corresponding author
29.Zhang JJ， Ma CY, Han X*, Durrin L, and Sun Y*. (2006). The BCL2 少校 breakpoint region (mbr) possesses transcriptional regulatory function. Gene 379：127-131. IF 2.69 *Co-corresponding author
30.Sun Y, Wang T, Yin Y, Xu S, Ma C, Han X* (2006). The behavior of SATB1, a MAR binding protein, in response to apoptosis stimulation. Cell Biology International. 30(3):244-247. IF 1.19 corresponding author
31.Wang Z, Lv JH, Zhang RH, ZyX, Sun Y, Zhu J, Han X*. (2006). Co-culture with fat cells induces 胰岛素 resistance in primary hepatocytes. BBRC 345 (3):976-83. IF 3.0 *corresponding author
32.Xu ZK, Chen NG, Ma CY, Meng ZX, Sun YJ, Han X*. (2006).Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion. Acta Biochim. Biophys. Sin. 38(1):1-7. IF 0.5 corresponding author
3.Lin J, Sun Y, Zhu D, Chen Q and Han X*. (2005). Potential role of NO in modulation of COX-2 expression and PGE2 production in pancreatic β-cells. Acta Biochimica et Biophysica Sinica 37(2):139-146. IF 0.5 corresponding autho
34.Han X, Chen S, Sun Y, Jerry L. Nadler, and Bleich D. (2002). Induction of cyclooxygenase-2 (COX-2) gene in pancreatic beta cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid (12-HETE). Molecular 内分泌学 19: 2145-2154.
35.Han X, Sun Y, Stephen Scott, and David Bleich. (2001). Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and b-cells. 糖尿病 50(5): 1047-55.
36.Han X, Lundberg P, Tanamachi B, Openshaw H, Longmate J, Cantin E.(2001) Gender influences herpes simplex 病毒 type 1 infection in normal and gamma interferon-mutant mice. J Virol. Mar; 75(6):3048-52.
生物化学与分子生物学（南京医科大学重点学科）.南京医科大学基础医学院.2021-04-23
韩晓.南京医科大学基础医学院.2021-04-23
38人！基金委医学科学部公布一项目评审专家名单.今日头条.2023-06-17
韩晓.南京医科大学.2021-12-11