伍一军 :伍一军

更新时间:2024-09-21 15:34

伍一军,男,安徽桐城人,毕业于佐治亚医学院分子医学与遗传学系基因调控专业,现为中国科学院动物研究所分子毒理学研究组组长、研究员,中国科学院大学兼职教授、博士研究生导师,中国昆虫学会第八届理事会常务理事、副秘书长。

人物经历

伍一军现任中国科学院动物学研究所研究员,博士研究生导师,主持分子毒理学实验室。中国科学院研究生院/动物研究所获得理学博士学位后赴美国Medical College of Georgia分子医学与遗传学系完成博士后研究训练。先后赴Jniversity of Louisiana、俄勒冈大学 Health\u0026Science University、Duke University、Virginia Commonwealth University等高校作为高级研究学者从事访问研究和合作研究。

正文

个人简介

伍一军,安徽桐城人。佐治亚州医学院分子医学与遗传学系基因调控专业博士后。现为中国科学院动物研究所分子毒理学研究组组长、研究员,中国科学院大学兼职教授、博士研究生导师,中国昆虫学会第八届理事会常务理事、副秘书长。主持分子毒理学实验室,专业方向为分子毒理学,主要研究领域为神经毒理学、环境毒理学以及药物引起的神经疾病。主要研究兴趣在于环境有害化学物质的神经毒性机制、神经病靶标酶引发迟发性神经毒性的分子机理、低剂量环境化学物质的致癌机理、溶血性贫血卵磷脂及泛蛋白调节在神经毒性发生过程中的作用等。先后主持中国科学院重点项目、国家自然科学基金项目、中科院生物特别支持项目、院创新项目和国际合作项目,并承担中科院创新重大项目和国家863专题项目。

主要论著

国际核心源刊物(SCI)

1.Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit iNTEracts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.

2.Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced ca(clo)2+response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80(6):886-892.

3.Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett, 2007, 424:22-26.

4.Chen R, Chang PA, Long DX, Yang L, Wu YJ. Down-regulation of neuropathy target esterase by protein kinase C activation with PMA stimulation. 摩尔 Cell Biochem. 2007, 302:179-185.

5.Yang L, Liu J, Wu YJ, Li W, Gao XW, Leng XF. Oral administrations of 甲胺磷 and TOCP have different effects on in vitro protein phosphorylation levels from subcellular fractions of hen brain. Pestic Biochem Physiol 2007, 88(1):20-25.

6.Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the nhancement of protein phosphorylation of 脑干 mitochondria and synaptosomes from the hens dosed with tri-o-cresyl 磷酸盐 Environ Toxicol Pharmacol. 2007, 24(1):67-71.

7.Chang 人民军, Long D-X, Wu Y-J. Molecular cloning and expression of chicken neuropathy target esterase activity domain. Toxicol. Lett. 2007, 174(1-3):42-48.

8.Chang PA, Long DX, Wu YJ. Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase. Mol 细胞 Biochem. 2007, 306:25-32

9.Li Q, Chen R, Li W, Qiao C-L, Wu Y-J. A genetically engineered 埃希氏菌属 coli, expressing the fusion protein of green fluorescent protein and carboxylesterase B1, can be easily detected in the environment following degradation of pesticide residues. Biotechnol Lett. 2007, 29(9): 1357-1362.

10.Li W, Wu Y-J,Qin 糖尿病,Ma Y,Sun Y-J,Qiu S-P.A method for quantifying azoxystrobin residues in grapes and soil using a gas chromatography capture detector. Chromatographia.2008, 67:761-766.

11.Li W, Qiu S-P, Wu Y-J. Triazophos residues and dissipation rates in wheat crops and soil. Ecotoxicol Environ Saf. 2008, 69:312-316.

12.Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159(1): 65-72.

13.Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39(5): 429-440.

14.Chang PA, Wu YJ. Effect of tri-o-cresyl 磷酸盐 on 细胞骨架 in human neuroblastoma SK-N-SH 细胞 摩尔 Cell Biochem. 2006, 290: 145-151.

15.Chang PA, Chen R, Wu YJ. Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SKNSH) 细胞 line. 摩尔 Brain Res 2005, 151: 30-38.

16.Chang PA, Wu YJ, Chen R, Li M, Li W, Qin QL. Inhibition of neuropathy target esterase expressing by antisense 核糖核酸 does not affect neural differentiation in human neuroblastoma (SKNSH) 细胞 line. 摩尔 Cell Biochem 2005, 272: 47-54.

17.Chang 人民军, Wu Y-J. Inhibition of the expression of neuropathy target esterase in human neuroblastoma cell SH-SY5Y by antisense 核糖核酸 and RNA interference. Acta Biochimica et Biophysica Sinica. 2004, 36(2):156.

18.Wu YJ, Harp P, Yan XR, Pope .cn Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterase. Chem-Biol Interact. 2003, 142(3):255-268.

19.Nozell S, Wu YJ, McNaughton K, Liu G, Willis A, Park JS, Chen XB. Characterization of p73 functional domains necessary for transactivation and growth 压制火炮 Oncogene, 2003, 22:4333-4347.

20.Wu YJ, Chang PA, Li M, Li YX, Li W. Effect of tri-O-cresyl 磷酸盐 and 甲胺磷 on 45CA uptake by brain synaptosomes in hens. Pestic Biochem Physiol. 2003, 77(1):18-23.

中文核心期刊

1.常平安,陈瑞,李薇,伍一军. 构建人神经病靶标酯酶RNAi表达载体抑制哺乳动物细胞中NTE的表达. 中华劳动卫生职业病杂志, 2006,24(1):27-30.

2.常平安,伍一军. 有机磷引起的迟发性神经病的发生机制。中华劳动卫生职业病杂志, 2006,24(6):382-384.

3.刘杰高希武,伍一军. 化学杀虫剂对松墨天牛体内代谢酶的作用. 农药, 2006,45(8):542-544.

4.常平安倪小敏,伍一军. 绿色荧光蛋白标记的NTE活性域表达载体的构建及表达. 重庆邮电大学学学报(自然科学版), 2006,18(3):416-419.

5.李薇,伍一军,仇绍萍,王睿,冷欣夫. 吡虫啉在萝卜及土壤中的残留动态研究. 农药, 2006,45(12):840-841.

6.龙鼎新,伍一军,李薇,王琦秦启联 8种化学药剂单独及两两联合染毒对松材线虫杀灭作用试验. 浙江林业科技, 2006, 26(5):39-42.

7.陈瑞,王仲文,伍一军. 电离辐射引发细胞凋亡的信号通路. 世界科技研究与发展, 2005,27(1):49-51.

8.伍一军,杨琳,李薇 有机磷农药的多毒性作用. 环境与职业医学, 2005,22(4):367-370.

9.杨琳,刘杰,李薇,伍一军. 甲胺磷诱发母鸡迟发性神经毒性模型. 动物学杂志,2005,40(4):12-16.

10.常平安,陈瑞,李薇,伍一军. NTE酯酶活性区域真核生物表达载体的构建及其表达. 毒理学杂志, 2005,19(3):169-171.

11.伍一军,陈瑞,李薇. 昆虫仿生. 昆虫知识, 2005,42(1):109-112.

12.伍一军,常平安,李薇秦启联陈瑞,刘承芸,冷欣夫。昆虫神经毒性酯酶活性的测定。昆虫知识, 2005,42(4):458-460.

13.伍一军,陈瑞,刘承芸,李薇. 农药残留及其纳米颗粒的毒性问题. 农药,2005,44(8):370-371-381.

14.常平安,伍一军. 有机磷酸酯诱发的迟发性神经病靶标酯酶的老化机制. 中国药理学与毒理学杂志, 2005,19(6):462-465.

15.伍一军,刘杰,杨琳,李薇,高希武 松墨天牛美国白灯蛾体内神经毒性酯酶和乙胆碱酯酶对甲胺磷敏感性的比较. 昆虫学报,2006, 49(3):399-403.

16.陈瑞,杨琳,姚智刘承云,李晓华,李琴,刘杰,常平安,李薇,伍一军. 神经病靶标酯酶调控结构域结合蛋白筛选及其在COS-7细胞中的表达. 动物学报,2005,51(5):840-844.

17.常平安,李明,伍一军。培养细胞在迟发性神经毒性研究中的应用。卫生毒理学杂志,2002,16 (4):245-247.

18.李明,常平安,李玉侠,李薇,伍一军。两种有机磷酸酯对人成神经细胞瘤细胞生长与钙摄取的影响。中华劳动卫生职业病杂志,2003,21(3):200-202.

19.常平安,伍一军。毒理蛋白质组学。中华预防医学杂志,2003,37(6):455-457.

20.伍一军,冷欣夫。杀虫脒药剂的神经毒理学研究进展。昆虫学报,2003,46(3):382-389.

21.Li M, Wu Y-J, Leng X-F. Effects of verapamil on 脑干 microsomal protein phosphorylation in vitro in hens dosed with tri-o-cresyl 磷酸盐 Chin J Pharmacol Toxicol 2002, 16(3): 165-171.

22.常平安,伍一军。有机磷酸酯引起的迟发性神经病的“强化”机理。中国药理学与毒理学杂志,2002,16(4):316-420.

23.伍一军。研究生创新思维和创新能力的培养。学位与研究生教育,2003,126(7):4-6.

24.冷欣夫、邱星辉、伍一军。细胞色素P450酶系循环催化的新途径。中国生物工程杂志,2002,22(5):49-52.

25.常平安,伍一军. 丙胺磷对人成神经细胞瘤SK-N-SH细胞分化的毒性机制. 中国药理学与毒理学杂志,2006,20(6):494-499.

26.常平安 , 伍一军. 反向重复序列法构建神经病靶标酯酶rna干涉表达质粒 毒理学杂志, 2007,21(1):4-8.

27.常平安,伍一军. 神经病靶标酯酶的特性。生命的化学,2004,24(5):424-426.

28.李晓华,龙鼎新,侯威远,李薇,伍一军. 溶血卵磷脂对小鼠及鸡脑突触体内钙离子浓度升高的影响. 动物学报, 2007, 49(3):399-403.

国际会议论文集论文

1. Liu J, Yang L, Li W, Gao XW, Wu YJ. Effects of 甲胺磷 and deltamethrin on protein phosphorylation of Monochamus alternatus Hope. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp97, China Agricultural University Press.

2. Yang L, Liu J, Li W, Wu YJ. The effect of 甲胺磷 on protein phosphorylation of adult hen’s brain. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp95, China Agricultural University Press.

3. Liu CY, Li W, Wu YJ. Study of apoptosis induced by 敌百虫 in SH-SY5Y cells. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing (Editor-in-chief: Jiang Shuren), pp100, China Agricultural University Press.

4. Li Q, Chen R, Li W, Qiao CL, Liu J, Liu CY, Li XH, Yang L, Wu YJ. Construction of GFP-marked genetically engineered bacteria used to degrade the pesticide residue in the environment. Proceedings of International Symposium on Pesticide and Environmental Safety, 2005, Beijing), (Editor-in-chief: Jiang Shuren), pp124, China Agricultural University Press.

5. Li W, Wu Y-J, Qin D-M, Ma Y, Qiu S-P. Determination of fungicide azoxystrobin residues in soil. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety \u0026 7th International Workshop on Crop Protection 化学 and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp225-230, 2007. China Agricultural University Press.

6. Li Q, Chen R, Wu Y-J. Generation of pesticides-degrading genetically engineered bacteria expressing the protein of GFP and carboxylesterase B1. In: Proceedings of 3rd International Symposium on Pesticide and Environmental Safety \u0026 7th International Workshop on Crop Protection 化学 and Regulatory Harmonization (October 9-13, 2007, Beijing, P. R. China) (Editor-in-chief: Jiang Shuren, Kenneth D. Racke), pp203-212, 2007. China Agricultural University Press.

专著

1.伍一军译. 第26章 陆生动物的毒液和毒素的毒效应. 见《卡萨瑞特道尔毒理学:毒物的基础科学》(第6版)(原著:Cartus D. Klaassen),黄吉武,周宗灿主译。北京:人民卫生出版社,2005:827-844.

2.彭双清郝卫东、伍一军. 《毒理学替代法》.北京:军事医学科学出版社,2009.

人才培养

伍一军已培养毕业研究生24人,多人获国家奖学金和中科院奖学金,毕业后赴美留学就业和博士后研究。国内工作中3人晋升为教授和硕导、5人晋升为副教授/副研究员。现有在读博士生3人,硕士生3人(其中联培生1人)。

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