更新时间：2024-09-21 03:30
崔磊，男，1968年生，医学博士，教授，博士生导师。任首都医科大学附属北京世纪坛医院中心实验室主任、整形科主任；兼同济大学医学院再生医学系教授、博士生导师。任中国整形美容协会抗衰老分会常务理事、中国医促会亚健康专业委员会肿瘤整形分会常委、中国生物医学工程学会理事, “中华医学科技奖”评审专家。1998年毕业于上海交通大学医学院。
崔磊，先后从事整形外科临床、干细胞与组织工程研究、临床应用转化等工作。历任“上海组织工程研究与开发中心”副主任、“组织工程国家工程中心”常务副主任等职务。目前主要研究方向集中于应用脂肪干细胞进行组织再造、组织修复、美容与抗衰老等方面。是国际组织工程领域的知名专家。主持的骨、角膜组织工程分别是我国第一个批准临床应用的组织工程技术。是我国最早结合脂肪干细 胞进行自体脂肪移植整形美容的专家之一。主持制定了我国首部《干细胞抗衰老技术规范化指南》并已正式发布。
承担国家“973”组织工程研究子项目、国家“863”重大专项、国家自然科学基金等多项课题。以第一或通讯作者发表SCI论文40篇(其中5分以上26篇)。截至2013年底，文章总他引645次，单篇最高篇他引95次。获授权发明专利15项。负责编写《黄家驷外科学》中组织工程章节。应邀为《Nature protocol》(IF:9.7)、《Biomaterials》(IF:8.3)、《Tissue Engineering 》(IF:4.5)等国际权威学术杂志审稿。
获国家技术发明二等奖(第二完成人)、教育部科技进步二等奖 (第一完成人)、上海医学科技二等奖等多种奖励。先后获上海市“曙光学者”、上海市“优秀学科带头人”、上海市科委“启明星”、“启明星后”、全国优秀青年骨干教师等人才奖励计划及荣誉。
组织工程技术的发展为创伤修复重建开辟了一条新途径。申请者在国内较早开展组织工程研究，开创性地进行了多种组织构建与组织修复工作，获2008年国家技术发明二等奖（第2完成人）。率先应用骨髓基质干细胞构建组织工程骨，完成骨缺损的多中心临床修复，获2008年教育部科技进步二等奖（第1完成人）。上述成果全面验证了组织工程技术临床应用的可行性。
脂肪干细胞（Adipose Derived Stem Cells, ADSCs）来源广泛、分选操作简单、扩增能力强，具有更大的潜在应用优势。崔磊教授围绕脂肪干细胞，重点进行了以下几个方面的研究：
1、率先应用成骨诱导ADSCs构建组织工程骨，成功修复大动物颅骨缺损。应用同种异体脂肪干细胞构建组织工程骨，成功修复了犬颅骨组织缺损；证明异体组织工程骨移植可实现免疫耐受。为组织工程骨从“个体化临床技术”向“产品的规模化临床应用”过渡，解决了核心难题。
2、创立完善的诱导体系，应用ADSCs体外构建具有优良力学强度的小口径组织工程血管。通过蛋白质组学分析，鉴别出多个与正常血管差异表达蛋白。这是组织工程血管蛋白质组学研究的首次报道。
3、通过合作研究，应用具有自主知识产权的聚L-谷氨酸支架，复合ADSCs，成功修复了体内关节软骨缺损与皮下脂肪的组织重建。研究为组织工程开辟了新的材料来源。
4、应用ADSCs组织工程技术，完成了关节软骨、硬膜外脂肪、角膜基质等多种组织的体内重建与组织修复，为ADSCs作为组织工程种子细胞提供了全面的证据。
1991-1993，首都医科大学附属北京世纪坛医院外科住院医师
1993-1998，上海交通大学医学院博士学位
1998-2001，上海第二医科大学附属第九人民医院整形科主治医师
2001-2005，上海第二医科大学附属第九人民医院整形外科副主任医师
2003-2012，上海组织工程研究与开发中心副主任
2004-2010，组织工程国家工程研究中心常务副主任
2006-2014，上海交通大学医学院附属第九人民医院整形外科教授、博导
2014-，同济大学医学院再生医学系教授、博导
2015-2021，首都医科大学附属北京世纪坛医院中心实验室主任、教授、博导
2017-，首都医科大学附属北京世纪坛医院整形科，代理主任
1. 组织工程化组织构建关键技术研发与应用
国家技术发明二等奖（2008）第2完成人
2. 干细胞构建组织工程骨的基础研究与临床应用
教育部科技进步二等奖（2007）第1完成人
3. 基于组织工程化角膜基质构建的角膜缺损修复研究
上海医学科技奖二等奖（2006）第1完成人
4. 组织工程皮肤的基础和应用研究
上海医学科技奖二等奖（2005）第3完成人
5. 组织工程化肌腱的应用基础研究
6. 修复骨组织缺损的组织工程学基础与临床应用研究
中国生物医学工程学会 理事
《中国医药生物技术杂志》 编委
中国整形美容协会抗衰老分会 常务理事
中国医促会亚健康专业委员会肿瘤整形分会 常委
1、《黄家驷外科学》（吴孟超、吴在德主编，人民卫生出版社2008年）
撰写“组织工程学”章节
2、《组织工程学》（曹谊林主编，科学出版社2007年）
副主编
3、《组织工程理论与实践》（曹谊林主编，上海科学技术出版社2004年）
副主编
1. Xue X, Liu Y, Wang Y, Meng M, Wang K, Zang X, Zhao S, Sun X, Cui L#, pan L, Liu S.MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN. Oncotarget. 2016 ; 7(51):84508-84519. (correspondence)
2. Yan S, Zhang X, Zhang K, Di H, Feng L, Li G, Fang J, Cui L#, Chen X, Yin J. Injectable in situ forming poly(L- glutamic acid) hydrogels for cartilage tissue engineering. J. Mater. Chem. B, 2016; 4: 947-961. (correspondence)
3. Zhang K, He S, Yan S, Li G, Zhang D, Cui L#, Yin J. Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly- (L-glutamic acid) based osteochondral scaffolds with induced autologous adipose derived stem cells. J. Mater. Chem. B, 2016; 4: 2628-2645. (correspondence)
4. Kaisaier A, Munila M, Abudusaimi A, Cui L#. Differentiation of human adipose derived stem cells into smooth muscle cells is modulated by CaMKII. Stem Cells Int. 2016 (19):1-9. (correspondence)
5. Li C, Bi W, Gong Y, Ding X, Guo X, Sun J, Cui L#, Yu Y. Transforming growth factor-beta1 inhibits tissue engineering cartilage absorption via inducing the generation of regulatory T cells. J Tissue Eng Regen Med. 2016;10(2):E113-20.(co-correspondence)
6. Gu H, Huang Z, Yin X, Lu L, Cui L#. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells. Exp Cell Res. 2015,339(1):112-21.(co- correspondence)
7. Zhang K, Yan S, Li G, Cui L#, Yin J. In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/ chitosan scaffold for hyaline-like cartilage regeneration. Biomaterials, 2015. 71: p. 24-34.(co-correspondence)
8. Sun W, Fang J, Yong Q, Li S, Xie Q, Yin J, Cui L#. Subcutaneous construction of engineered adipose tissue with fat lobule-like structure using injectable poly-Benzyl-L-Glutamate microspheres loaded with adipose-derived stem cells. PLoS One, 2015. 10(8): p. e0135611.(co-correspondence)
9. Gu H, Huang Z, Yin X, Zhang J, Gong L, Chen J, Rong K, Xu J, Lu L, Cui L#. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells. Exp Cell Res, 2015. 339(1): p. 112-21.(世界斯诺克中国公开赛correspondence)
10. Fang J, Zhang Y, Yan S, Liu Z, He S, Cui L#, Yin J. Poly(L-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration. Acta Biomater. 2014 Jan;10(1):276-88.(co- correspondence)
11. Zhang K, Zhang Y, Yan S, Gong L, Wang J, Chen X, Cui L#, Yin J. Repair of an articular cartilage defect using adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid) and chitosan. Acta Biomater. 2013 Jul;9(7):7276-88.(co-correspondence)
12. Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L#. Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.Tissue Eng Part A. 2014 Feb;20(3-4):575-87(correspondence)
13. Liu G, Zhang Y, Liu B, Sun J, Li W, Cui L#. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials. 2013 Apr;34(11):2655-64.(correspondence)
14. Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L#. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells. Tissue Eng Part A. 2013 ;19:415-25.(correspondence)
15. Xu J, Chen Y, Yue Y, Sun J, Cui L#. Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the 兔形目 dorsal laminectomy model. Biomaterials. 2012 ;33(29):6965-73.
(correspondence)
16.Chen F, Zhang W, Wu W, Jin Y, Cen L, Kretlow JD, Gao W, Dai Z, Wang J, Zhou G, Liu W, Cui L#, Cao Y. Cryopreservation of tissue-engineered epithelial sheets in trehalose. Biomaterials. 2011 Nov;32(33):8426-35.(co-correspondence)
17. Gao WC, Ma SL, Cui L#. Adipose-derived stem cells accelerate neovascularization in ischemic diabetic skin flap via expression of hypoxia-inducible factor-1. J Cell 摩尔 Med. 2011;15:2575-85.(co-correspondence)
18. Gu H, Guo F, Zhou X, Gong L, Zhang Y, Zhai W, Chen L, Cen L, Yin S, Chang J, Cui L#. The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway. Biomaterials. 2011; 32:7023-33.(co-correspondence)
19. Cao B, Yan S, Zhang K, Song Z, Chen X, Cui L#, Yin J. Layer-by-layer assembled multilayer films of methoxypoly (乙烯 glycol)-block-poly(l-glutamic acid) and chitosan with reduced cell adhesion. Macromol Biosci. 2011;11:1211-7(co－correspondence)
20. Yan S, Yin J, Cui L#, Yang Y, Chen X. Apatite-forming ability of bioactive poly(l-lactic acid)/grafted silica nanocomposites in simulated body fluid.Colloids Surf B Biointerfaces. 2011;86(1):218-24.(世界斯诺克中国公开赛correspondence)
21. Cao B, Yan S, Zhang K, Song Z, Cao T, Chen X, Cui L#, Yin J. A poly(acrylic acid)-block-poly(L-glutamic acid) diblock copolymer with improved cell adhesion for surface modification. Macromol Biosci. 2011;11(7):970-7.(世界斯诺克中国公开赛correspondence)
22. Cao B, Yin J, Yan S, Cui L#, Chen X, Xie Y. Porous scaffolds based on cross-linking of poly(L-glutamic acid). Macromol Biosci. 2011;11(3):427-34(co-correspondence)
23. Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L#. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage-derived morphogenetic protein 1. Tissue Eng Part A. 2010;16: 1633-43.(世界斯诺克中国公开赛correspondence)
24. Yuan J, Zhang WJ, Liu G, Wei M, Qi ZL, Liu W, Cui L#, Cao YL. Repair of canine mandibular bone defects with bone marrow stromal cells and coral. Tissue Eng Part A. 2010;16:1385-94.(co-correspondence)
25. Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L#.Differentiation of adipose-derived stem cells into contractile smooth muscle cells induced by transforming growth factor-beta1 and bone morphogenetic protein-4. Tissue Eng Part A. 2010;16:1201-13.(co-correspondence)
26. Liu G, Li Y, Sun J, Zhou H, Zhang W, Cui L#, Cao Y. In vitro and in vivo evaluation of osteogenesis of human umbilical cord blood-derived mesenchymal stem cells on partially demineralized bone matrix. Tissue Eng Part A. 2010;16:971-82.(世界斯诺克中国公开赛correspondence)
27. Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L#. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials. 2010;31:621-30.(co-correspondence)
28. Wang HJ, Liu GP, Zhou GD, Cen L, Cui L#, Cao Y. Comparative investigation of viability, metabolism and osteogenic capability of tissue-engineered bone preserved in sealed osteogenic media at 37 degrees C and 4 degrees C. BIOMEDICAL MATERIALS 2010; 5: 035010(co-correspondence)
29. Liu Q, Cen L, Zhou H, Yin S, Liu G, Liu W, Cao Y, Cui L#. The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone. Tissue Eng Part A. 2009;15:3487-97.(co-correspondence)
30. Cui L#, Wu YH, Cen L, et al. Repair of Articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials. 2009; 30:2683-2693(first author)
31. Zhao GQ, Yin S, Cen L, Cao Y, Cui L#. In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide. Biomaterials.2009;30:3241-50.(co-correspondence)
32. Lian Cen, Koon Gee Neoh, Jian Sun, Cao Y, Cui L#. Labeling of adipose derived stem cells by oleic acid modified magnetic nanoparticles. Advanced Func.Mater.2009; 19: 1158-66.(co-correspondence)
33. Liu Q, Cen L, Yin S,Cao Y, Cui L#. A comparative study of proliferation and osteogenic differentiation of adipose- derivedstem cells on akermanite and beta-TCP ceramics. Biomaterials. 2008; 29: 4792-4799.(co- correspondence)
34. Luo K, Yin J, Song Z, Cui L#, Yin J. Biodegradable Interpolyelectrolyte Complexes Based on Methoxy Poly(乙烯 glycol)-b-poly(alpha,l-glutamic acid) and Chitosan. Biomacromolecules. 2008; 9:2653-61(co- correspondence)
35. Liu G, Zhou H, Li Y, Cao Y, Cui L#. Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology. 2008; 57:18-24,(co-correspondence)
36. Cui L#,Liu B,Liu GP, et al. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials. 2007; 28:5477-5486(first author)
37. Jiang XG, Ye ML, Jiang XM, Cao Y, Cui L#. Exploring the bone proteome: from protein identification to protein 函数 Method development of efficient protein extraction in bone tissue for proteome analysis, J. Proteome Res., 2007,6:2287-2294.(co-correspondence)
38. Cui L#,Yin S, Liu W, Li NL, Zhang WJ, Cao YL. Expanded adipose derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng, 2007; 13: 1185-95(first author)
39. Jie Yuan, Cui L#, Wen Jie Zhanga, Wei Liu,Yilin Cao. Repair of canine mandibular bone defects with bone marrow stromal cells and porous b-tricalcium 磷酸盐 Biomaterials. 2007; 28: 1005-13(co-first author)
崔磊.首都医科大学附属北京世纪坛医院.2022-01-17