更新时间：2024-09-21 01:28
李勇，男，安徽大学生命科学学院教授。主要研究肿瘤的发病机制，特别是肿瘤细胞的转移及侵润机制。主要对肿瘤发展中一些基因的异常表达，以及这些基因的功能，转录及翻译等的调控机制和信号通路等方面的研究，从而发现抑制这些基因表达和功能的方法。
肿瘤转移是一个多步骤复杂的过程，主要是指肿瘤细胞从原发灶组织转移到在续发组织上存活且生长成恶性肿瘤的过程。肿瘤转移（metastasis）是肿瘤病人死亡的主要原因，计占死亡总数的90%左右。因此，阐明肿瘤细胞转移的分子机制具有非常重要的意义。
1. 各种基因的转录增强子，抑制子和他们的调节因子是如何结合并共同调控癌基因的表达；
2. 肿瘤细胞是如何对胞外信号进行反应，胞外信号是如何传递的细胞内并调控基因的转录和翻译；
3. 肿瘤细胞中癌基因是如何具体转录和翻译的；
4. 肿瘤细胞的转移及侵润机制；
5. 肿瘤细胞的微环境是如何影响肿瘤的发展机理；
6. 肿瘤细胞的epithelia-mesenchymal transition机制。
目前，我从事的研究是阐明细胞外各种因子和信号是如何共同通过影响肿瘤细胞膜上的受体，从而改变细胞的骨架及胞内的信号传递途径，并进一步使肿瘤细胞获得转移和侵润的能力。
Metastasis is a complex process that involves the spread of a tumor or cancer to distant parts of the body from its original site. It is of great importance since most of the cancer deaths are caused by spread of the primary cancer to distant sites, and metastatic cancer is responsible for 90% of cancer deaths. Therefore, it is very important to elucidate the molecular mechanisms of cancer metastasis.
My research interests center on dissecting the 建筑 and function of genes and their regulatory networks, and identifying the molecular mechanisms of gene expression regulation in cancer progression and metastasis. My research areas including:
1. How the multiple transcriptional enhancers, repressors and boundary elements connect to genes and orchestrate the expression of genes.
2. how cells receive extracellular signals and signal transduction,
3. genes transcription and translation,
4. gene mutations and altered gene expression in cancer,
5. tumor cell invasion and metastasis,
6. stromal cell/ tumor interactions and,tumor stem cells,
7. epithelia-mesenchymal transition study, etc.
Currently I am focusing on the molecular mechanisms how extracellular and oncogenic signals through coordinated changes in membrane traffic and the actin cytoskeleton promote the acquisition of a migratory / invasive phenotype characteristic of tumor cells.
主要成员
戎芳，晁凤梅
阐明钙粘附蛋白－11（cadherin 11）在乳腺癌细胞中的转录调控机制，以及钙粘附蛋白－11促进肿瘤细胞转移的分子机制。
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2. Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S. Ratio of miR-196s to HOXC8 messenger 核糖核酸 correlates with breast cancer cell migration and metastasis. Cancer Res.
3. Li Y, Kimura T, Tuyck RW, Laity JH, Andrews GK, Zinc-induced formation of a co-activator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP and Sp1. 摩尔 Cell. Biol.2008; 28: 4275-4284.
4. Li Y, Kimura T, Laity JH, Andrews GK, The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers. Mol Cell Biol. 2006 Aug; 26(15):5580-7.
5. Okumura F, Li Y, Itoh N, Nakanishi T, Isobe M, Andrews GK, Kimura T. The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter. Biochim Biophys Acta. 2011 Jan;1809(1):56-62
6. Chen H, Zhu G, Li Y, Padia RN, Dong Z, pan ZK, Liu K, Huang S, Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. Cancer Res
7. Kimura T, Li Y, Okumura F, Itoh N, Nakanishi T, Sone T, Isobe M, Andrews GK, Chromium (VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem J. 2008 Nov 1; 415(3):477-82.