欧阳松应 博士 研究员，男，中国科学院青年创新促进会会员，北京市科技新星计划入选者。

基本信息

欧阳松应 博士 研究员

中国科学院青年创新促进会会员

北京市科技新星计划入选者

研究方向：病原体感染与脱氧核糖核酸识别天然免疫反应分子机制研究

研究工作

1997.07-2001.09 南昌大学 生物科学工程系 学士

2001.08-2004.07 吉林大学（农学部）生物化学与分子生物学教研室 硕士

2004.08-2007.06 中国协和医科大学 基础所生物化学与分子生物学系 博士

2007.07-2010.08 中国科学院生物物理研究所 助理研究员

2010.09-2013.11 中国科学院生物物理研究所 副研究员

2013.12-至今 中国科学院生物物理研究所 研究员

（2013年12月获中国科学院生物物理研究所“青年研究员计划”支持）

获奖情况

2014年度北京市科技新星计划入选者

2013年荣获中科院“卢嘉锡青年人才奖”

研究方向

病毒感染与脱氧核糖核酸识别天然免疫反应分子机制研究

代表论文

1. Jiao L*, Ouyang S*, Shaw N, Song G, Feng Y, Niu F, Qiu W, Zhu H, Hung LW, Zuo X, Shtykova E, Zhu P, 越南盾 YH, Xu R#, Liu ZJ#. Mechanism of the Rpn13-induced activation of Uch37

2. Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D, Du C, Yang Y, Ouyang S#, Liu ZJ#, Han W#. Structural and biochemical characterization reveals LysGH15 as an unprecedented “EF-hand-like” 一水合醋酸钙binding phage lysin

3. Zhang L, Mo J, Swanson K, Wen H, Petrucelli A, Gregory S, Zhang Z, Schneider M, Jiang Y, Fitzgerald K, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan J, Ting J. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the 脱氧核糖核酸 sensor STING

4. Zhao L*, Hua T*, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Jiang Y, Hung LW, Liu L, Ye K, Ouyang S#, Cheng G#, Liu ZJ#. Structural analysis of 美国电力公司 reveals activation mechanism and reversible maturation intermediate. Cell Res

5. Niu F, Ru H, Ding W, Ouyang S#, Liu ZJ#. Structural biology study of human TNF receptor associated factor 4 TRAF domain

6. Niu F*, Shaw N*, Wang Y*, Jiao L*, Ding W, Upurd H, Ouyang S#, Cheng G#, Liu ZJ#. From the Cover: Structure of the LeanyerOrthobunyavirus NucleoproTEIN核糖核酸 complex reveals novel 建筑 for RNA encapsidation

7. Jiao L*, Ouyang S*, Liang M*, Niu F*, Shaw N, Wu W, Ding W, Jin C, Peng Y, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ. Structure of severe fever with thrombocytopenia Syndrome 病毒 nucleoprotein in complex with Suramin reveals therapeutic potentials

8. Shaw N, Ouyang S, Liu ZJ. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

9. Parvatiyar K*, Zhang Z*, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

10. Ouyang S*, Song X*, Wang Y*, Ru H*, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G, Liu ZJ. Structural Analysis of the Sting Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic DIGMP Binding

11. Zhan Z*, Ouyang S*, Liang W, Zhang Z, Liu ZJ, Huang L. Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase

12. Ouyang S*, Gong B*, Li JZ*, Zhao L*, Wu W, Zhang FS, Sun L, Wang SJ, pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y, Liu ZJ, Liang M. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

13. Liang W*, Ouyang S*, Shaw N, Joachimiak A, Zhang R, Liu ZJ. Conversion of D-ribulose 5-磷酸盐 to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE

14. Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II protein/APLP2 stability

15. Yin XQ*, Ouyang S*, Xu WM*, Zhang XP, Fok K.L., Zhang JP, Miao SY, Chan HC, and Wang LF. YWK-II as a novel Go protein-coupled 捕手 for Müllerian Inhibiting Substance in cell survival. J Cell Sci

16. Qiu XB*, Ouyang S*, Li CJ, Miao S, Wang L, Goldberg AL. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37

人物成就

2022年9月23日消息，福建师范大学生命科学学院欧阳松应教授团队联合福建佰孟医学科技有限公司，成功研发猴痘病毒荧光PCR检测试剂盒（荧光探针法），并取得欧盟CE认证，获得CE注册证书。这意味着该试剂盒可在欧盟国家以及认可欧盟CE认证的国家销售。

参考资料

福建省成功研发猴痘病毒检测试剂盒.今日头条·台海网.2022-09-24