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闫兵，山东大学教授，美国哥伦比亚大学化学系博士毕业，山东大学长江学者特聘教授，博士生导师，组合化学研究所所长。主要从事组合化学、纳米医药及纳米毒理学和新型抗癌药物研发等方面的研究。前后发表论文七十余篇，代表作Steering 碳 Nanotubes to Scavenger Receptor Recognition by Nanotube Surface 化学 Modification Partially Alleviates NF¦ÊB Activation and Reduces Its Immuno毒性 参与并完成了多项科研项目。
1978年2月，闫兵考入山东大学化学系，后于1982年1月顺利毕业并获得学士。1986年9月，他前往美国哥伦比亚大学深造。在哥伦比亚大学，他首先于1986年9月至1989年10月间获得了硕士学位，同时期也完成了哲学硕士的学习。1989年9月，他继续在哥伦比亚大学读博，最终于1990年10月顺利毕业获得了博士学位。
1993年7月，闫兵进入美国新泽西州的诺华集团，担任高级副研究员。1999年7月，他出任了加利福尼亚州南旧金山的国际探索合作伙伴的分析科学部主任。2004年3月，他加入了美国康涅狄格州沃林福德的百时美施贵宝生物医学研究所，担任高级主任科学家。2007年，他在美国田纳西州孟菲斯的裘德儿童研究医院担任教授，并兼任高通量新药研发分析中心主任（后于2012年卸任）。2005年11月，他作为特聘教授回到山东大学化学与化工学院及环境科学与工程学院任教，后于2017年9月离职。2017年，他再次作为特聘教授加入广州大学大湾区环境研究院环境污染与健康团队。
1993年至1999年受聘于位于新泽西州的诺华 Biomedical Research Institute。他负责创建的研究团队是美国最先投入组合化学研究的团队之一，最先建立了组合化学中应用于固相高通量合成技术中的分析和检测方法及反应动力学研究，推动了固相合成和组合化学的发展。
据不完全统计，闫兵博士在1996年发表在Journal of Organic Chemistry 上该领域内的首创性论文被144次引用，他在该领域发表的7篇主要论文被引用次数迄今为止已超过625次。其研究成果很快得到了国际学术界的公认和好评，并被美国化学学会ACS 出版发行的Chemical Engineering News （April6, 1998）报道。
1998年，他和其他学术带头人在Anthony Czarnic 博士的带领下为美国化学学会创刊发行了Journal of Combinatorial 化学 （JCC），并担任两届编委至今。现任该杂志副主编。
1999年至2005年，他受聘于美国Discovery Partners International和Bristal-Myers Squibb，在组合化学中的合成、纯化和质量控制及用于早期药物开发的高通量筛选领域从事研究工作。
2001年当选为Sigma Xi成员，并于2002及2004年应邀在匹兹堡会议上组织和主持了两次国际专题研讨会：PittCon 2002 和 PittCon 2004。
于2007年在 FACSS会议上主持国际专题会议。
闫兵博士组织并主持国际学术会议6次，17次应邀在国际学术会议上作大会报告或特约报告，在分析化学和组合化学分析领域撰写专著4部，主编著作4部，并发表了11部书章节或综述文 章，在Nature, Proc.Natl.Acad.Sci.USA, Curr.Opin.Chem.Biol., Acc. Chem.Res., Biochemistry, Biophys. J., Nano Lett., J.Med.Chem., Anal.Chem., J. Biol.Chem.和J.Comb.Chem.等杂志上发表论文74篇，发表论文被他人引用超过1530次。
主要从事组合化学、纳米医药及纳米毒理学和新型抗癌药物研发等领域的研究。他负责创建的研究团队是国际上最先投入组合化学研究的团队之一，最先提出了大量组合化学中应用于固相高通量合成技术中的分析和提纯方法，推动了固相合成和组合化学的全面发展。据不完全统计，1996年他发表在Journal of Organic Chemistry上该领域内的首创性论文被130次引用，他的7篇主要论文被引用次数迄今为止已超过500次。其在组合化学中的合成、纯化和质量控制及用于早期药物开发的高通量筛选领域的研究达到世界领先地位，许多由他及其助手开发出的化合物被用于药物的临床实验。主持国家自然科学技基金委项目“应用组合化学和高通量筛选技术开发新型特效饮用水除剂”（项目批准号 20577029），2006。在分析化学和组合化学分析领域撰写专著4部，参与另外11部书章节或综述文章的编写工作，在高影响因子SCI杂志上发表论文70余篇，发表论文被他人正面引用超过1280次。
We use modern discovery tools such as combinatorial 化学, high-throughput screening, computation and biological techniques to study some fundamental problems and processes in biology and medicine. Our research directions are two fold: the first is to modulate biological specificities of nanomaterials by controlling their surface 化学 to study their surface structure-activity and structure-毒性 relationships and discover biocompatible and cancer targeting nanomedicine and nanodiagnostics; the second is to develop anti-cancer chemical agents that target drug resistant cancers or molecular probes to understand biological processes. The drug development is a very long process. Our focus is to discover and optimize lead compounds, study the mechanism of action, and complete preclinical research for top candidates. We also develop various drug discovery and analytical chemistry technologies to assist our research goals and train graduate students (摩托船 and Ph.D.) and postdoctoral fellows.
1. Gao NN, Zhang Q, Mu QX, Bai YH, Li LW, 周姓 HY, Butch E, Powell T, Snyder SE, Jiang GB, Yan B.* Steering 碳 Nanotubes to Scavenger Receptor Recognition by Nanotube surface 化学 Modification Partially Alleviates NF¦ÊB Activation and Reduces Its Immuno毒性 ACS Nano, Web Publication Date: May 19, 2011.
2. Li LW, Zhang Q, Liu AF, Li, XE, Zhou HY, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. J Am Chem Soc 2011, 133(18), 6886-6889.
3. Zhou HY, Jiao PF, 严姓g L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J Am Chem Soc 2011, 133(4), 680-682.
4. Yu C, 张姓 J, Chen L*, Li J, Liu P, Wang W, Yan B.* ¡°Off-On¡± Based Fluorescent Chemosensor for Cu2+ in Aqueous Media and Living Cells. Talanta 2011, in press.
5. Liu YJ, Zhang B, Yan B.* Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of 紫杉醇 Int J 摩尔 Sci2011, in press.
6. Andersson AK, Miller DW, Lynch J, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. IDH1 and IDH2 Mutations in Pediatric Acute 白血病 Leukemia, Web Publication Date: June 7, 2011.
7. Hurdle JG, Heathcott AE, Yang L, Yan B, Lee RE. Reutericyclin and Related Analogues Kill Stationary Phase Clostridium Difficile at Achievable Colonic Concentrations. J Antimicrob Chemother Web Publication Date: May 31, 2011.
8. Tekobo S, Richter AG, Dergunov SA, Pingali SV, Urban VS, Yan B, Pinkhassik E. Synthesis, Characterization, and Controlled Aggregation of Biotemplated Organic Nanodisks. J Nanoparticle Research, Web Publication Date: May 11, 2011.
9. 周姓 QF, Dergunov SA, 张姓 Y, Li X, Mu QX, Zhang Q, Jiang GB, Pinkhassik F, 严姓 B.* Safety profile and cellular uptake of biotemplated nanocapsules with nanometer-thin walls. Nanoscale, Web Publication Date: April 20, 2011.
10. Wu L and Yan B.* Discovery of Small Molecules that Target Autophagy for Cancer Treatment. Current Medicinal 化学 2011, 18(12), 1866-1873.
11. Yan B. Impacts of NanoTechnology on Medicinal Chemistry and Drug 探索频道 Current Medicinal Chemistry 2011, 18(14), 2044.
12. Jiao P, 周姓 H, Chen L, Yan B.* Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy. Current Medicinal 化学2011, 18(14), 2086-2102.
13. Yan B, Editorial: Nano-Combinatorial Chemistry and Associated Technologies, Combinatorial Chemistry \u0026 High Throughput Screening 2011, 14(3), 146.
14. Zhang W, Penmatsar H, Ren A, Punchihewa C, Lemoff A, Yan B, Fujii N and Naren AP. Functional Regulation of CFTR-Containing Macromolecular Complexes: A Small-Molecule Inhibitor Approach. Biochemical Journal 2011, 435, 451¨C462 (Highlighted by Commentary "Targeting the regulation of CFTR channels" by Paul DWE and Christine EB, Biochem J 2011, 435, e1¨Ce4).
15. Liu Y, Yan B.* Characterizing the surface 化学 of Nanoparticles: An Analogy to 固体-Phase Synthesis Samples. Combinatorial Chemistry \u0026 High Throughput Screening2011, 14(3), 191-197.
16. Li X, Zhou HY, Yang L, Du GQ, Pai-Panandiker A, Huang XF, and Yan B.* Enhancement of 细胞 Recognition in vitro by Dual-Ligand Cancer Targeting Gold Naoparticles. Biomaterials 2011, 232, 2540-2545.
17. Gasser M, Rothen-Rutishauser B, Krug HF, Gehr P, Nelle M, Yan B and Wick P. The 吸附 of Biomolecules to Multi-Walled 碳 Nanotubes is Influenced by Both Pulmonary 表面活性剂 Lipids and surface 化学 Journal of Nanobiotechnology 2010, 8:31.
18. Liu YY, Su GX, Zhang B, Jiang GB, Yan B.* Nanoparticle-Based Strategies for Detection and Remediation of Environmental Pollutants. Analyst 2011, 136(5), 872-877 (设计ated by Royal Society of 化学 as one of the top five most-read articles from the online version of Analyst for February 2011).
19. Wang GQ, Chen ZP, Wang WH, Yan B and Chen LX. Chemical Redox-Regulated Mesoporous Silica-Coated Gold Nanorods for Colorimetric Probing of Hg2+ and S2 Analyst, 2011, 136(1), 174-178.
20. Wang F, Zhai SM, Liu XJ, Li LW, Wu S, Dou QP* and Yan B.* A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition has 铜Dependent Proteasome-Inhibitory and Apoptosis¨CInducing Activity in Human Breast Cancer Cells. Cancer Letters 2011, 300(1), 87-95.
21. Mu, Q.X., Li, Z.W., Li, X., Mishra, M.R., Zhang, B., Si, Z.K., Yang, L., Jiang, W., Yan, B.* (2009) Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells.J Phys Chem C (In press).New!
22. Ma, X.F., Shi, R.R., Zhang, B., Yan, B.* (2009) Kinetics of Resin-Supported Mitsunobu Esterification and Etherification Reactions.J Comb Chem (In press).New!
23. Du, F.F., Zhou, H.Y., Chen, L.X., Zhang, B., Yan, B.* (2009) Structure Elucidation of Nanoparticle-Bound Organic 摩尔ecules by H NMR.Trends in Analytical 化学 28(1), 88-95.New!
24. Zhou, H.Y., Du, F.F., Li, X., Zhang, B., Li, W., Yan, B.* (2008) Characterization of Organic Molecules Attached to Gold Nanoparticle surface Using High Resolution Magic Angle Spinning H NMR.J Phys Chem C 112(49), 19360-19366.New!
25. Yu, Y.M., Zhang, Q., Mu, Q.X., Zhang, B., Yan, B.* (2008) Exploring the Immunotoxicity of 碳 Nanotubes.Nanoscale Research Letters 3(8), 271-277.New!
26. Lemoff. A and Yan, B.* (2008) Dual Detection Approach to a More Accurate Measure of Relative Purity in High-Throughput Characterization of Compound Collections.J Comb Chem 10(5), 746-751.New!
27. Zhou, H.Y., Mu, Q.X., Gao, N.N., Liu, A.F., Xing, X.Y., Gao, sl, Zhang, Q., Qu, G.B., Chen, Y.Y., Liu, G., Zhang, B., Yan, B. (2008) A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response.Nano Letters 8(3), 859-865.New!
28. Qi, M.H., Zhou, H.Y., Ma, X.F., Zhang, B., Jefferies, C., Yan, B. (2008) Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle.J Comb Chem 10(2), 162-165.
29. Mu, Q.X., Liu, W., Xing, Y.H., Zhou, H.Y., Li, Z.W., Zhang, Y., Ji, L.H., Wang, F., Si, Z.K., Zhang, B., Yan, B. (2008) Protein Binding by Functionalized Multiwalled 碳 Nanotubes Is Governed by the surface 化学 of Both Parties and the Nanotube Diameter.J Phys Chem C 112(9), 3300-3307.
30. Zhou, H.Y., Wu, S.H., Zhai, S.M., Liu, A.F., Sun, Y., Li, R.S., Zhang, Y., Ekins, S., Swaan, P.W., Fang, B.L., Zhang, B., Yan, B. (2008) Design, Synthesis, Cytoselective 毒性, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer 细胞J Med Chem 51(5), 1242-1251.
31. Zhou, H., Liu, A., Li, X., Ma, X., Feng, W., Zhang, W., Yan, B. (2008) 微波Assisted Fluorous Synthesis of 4-Aryl-Substituted Thiazolidinone and Thiazinanone Libraries.J Comb Chem 10(2), 303-312.Hot! (One of the Most Accessed Article 2008 from ACS Publications)
32. Zhang, B., Li, X.F., Yan, B. (2008) Advances in HPLC Detector-Towards Universal Detection.Anal Bioanal Chem 390(1), 299-301.
33. Yu, Z.Y., Wang, F., Milacic, V., Li, X.F, Cui, Q.C, Zhang, B., Yan, B., Dou, Q.P. (2007) Evaluation of 铜Dependent Proteasome-Inhibitory and Apoptosis-Inducing Activities of Novel 四氢吡咯 Dithiocarbamate Analogs.Int J Mol Med 20(6), 919-925.
34. Xu, P., 裘姓, J.H., Zhang, Y.N., Chen, J., Wang, P.G., Yan, B., Song, J., Xi, R.M., Deng, Z.X., Ma, C.Q. (2007) Efficient Whole-Cell Biocatalytic Synthesis of N-Acetyl-D-Neuraminic Acid.Advanced Synthesis \u0026 Catalysis 349(10), 1614-1618.
35.Yan, B., Shi, R., Zhang, B., Kshirsagar, T. (2007) A Kinetic Study of Product CLEAVAGE Reactions from the Solid Phase by a Biocompatible and Removable Cleaving Reagent, HCl.J Comb Chem 9(4), 684-689.
36. Shi, R., Wang, F., Yan, B. (2007) Site-Site Isolation and Site-Site Interaction - Two Sides of the Same Coin.Int J Pept Res \u0026 Therapeutics 13(1-2), 213-219.
37. Chen, D., Cui, Q.C., Yang, H., Barrea, 类风湿性关节炎, Sarkar, 家族性高胆固醇血症, Sheng, S., Yan, B., Reddy, G.P.V., Dou, Q.P. (2007) Cliquinol, a Therapeutic Agent for Alzheimer’s Disease, Has Proteasome-inhibitory, Apoptosis-inducing and Anti-tumor Activities in Human Prostate Cancer Cells and Xenografts.Cancer Res 67(4), 1636-1644.
38. Yan, B., Zhao, J., Leopold, K., Zhang, B., Jiang, G. (2007) The Structure Dependent Response of Chemiluminescence 氮 Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond.Anal Chem 79 (2), 718-726.
39. Daniel, 千克, Chen, D., Yan, B., Dou, Q.P. (2007) 铜Binding Compounds as Proteasome Inhibitors and Apoptosis Inducers in Human Cancer.Front Biosci 12, 135-144.
40. Zhai, S., Liu, W., Yan, B. (2007) Recent Patents on Treatment of Severe Acute Respiratory 综合征 (严重急性呼吸综合征).Recent Patents on Anti-Infective Drug Discovery 2(1), 1-10.
41. Chen, L., Choo, J., Yan, B. (2007) The Microfabricated Electrokinetic Pump: A Potential Promising Drug Delivery Technique.Expert Opin Drug Deliv 4(2), 119-129.
42. Landis-Piwowar, 丹麦克朗, Milacic, V., Chen, D., Yang, H., Zhao, Z.Y., Chan, T.H., Yan, B., Dou, Q.P. (2006) Discovering Novel Anticancer Drugs and Chemo-Sensitizers by Using the Proteasome as a Potential Target.Drug Resistance Update 9, 263-273.
43. Wu, S., Guo, W., Teraishi, F., Pang, J., Kaluarachchi, K., Zhang, L., Davis, J., 越南盾, F., Yan, B., Fang, B. (2006) Anticancer Activity of 5-Benzylide氖2-Phenyllimino-1,3-Thiazolidin-4-one (BPT) Analogs.Med Chem 2(6), 597-605.
44. 成姓, X., Yan, B., Gao, L., Tang, H., Fan, Y., Anderson, S. N., Affleck, R., Burns, D. (2005) 化合物 Transfer Efficiency from 聚苯乙烯 Surfaces-Application to Micro-Arrayed Compound Screening.J Biomolecular Screening 10(4), 293-303.
45. Irving, M., Krueger, C. A., Wade, J. V., Hodges, J. C., Leopold, K., Chan, C., Shaqair, S., Shornikov, A., Stock, M., Collins, N., Yan, B. (2004) High-Throughput Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member 4-Amidopyrrolidinone Library.J Comb Chem 6, 478-486.
46. Yan, B., Collins, N., Wheatley, J., Irving, M., Leopold, K., Chan, C., Shornikov, A., Fang, L., Lee, A., Stock, M., Zhao, J. (2004) High-Throughput Purification of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window Approach.J Comb Chem 6, 255-261.
闫兵.x-mol.2024-07-12