更新时间：2024-09-20 19:34
陈实，教授，博士生导师，美国微生物科学院Fellow、国家基金委杰出青年基金获得者。
2004年明治乳业生命科学优秀奖
2004年上海-联合利华公司研究与发展基金奖学金
2004年上海市新长征突击手“标兵”
2004年新加坡陈嘉庚基金会第二届陈嘉庚青少年发明奖（上海）（银奖）
2006年上海市研究生学位论文优秀成果
2007年《环球科学》2007年度全球十大科学新闻
2007年上海市优秀发明奖选拔赛二等奖
2007年新加坡陈嘉庚基金会第五届陈嘉庚青少年发明奖（上海）（铜奖）
2008年国家自然科学奖二等奖
2008年新加坡陈嘉庚基金会第六届陈嘉庚青少年发明奖（上海市）（铜奖）
2012年武汉大学医学部医学突出贡献奖
2014年中国微生物学会学术年会优秀学术论文奖
2015年高等学校科学研究优秀成果奖自然科学一等奖
2015年武汉大学医学部医学突出贡献奖
2016年中国微生物学会学术年会优秀学术论文奖
2017年湖北省医学领军人才
2017年武汉大学杰出青年（教职工）
2018年武汉大学朱裕璧医学奖
2019年国家基金委杰出青年基金
2020年美国微生物科学院Fellow (Fellow of American Academy of Microbiology)
1．基因组修饰及编辑
2．脱氧核糖核酸骨架的磷硫化生理修饰
3．创新药物的设计与改造
1.Chen C, Wang L, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114.
2.Tong T#, Chen S#, Wang L#, Tang Y#, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and 函数s of 脱氧核糖核酸 phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115.
3.Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of 脱氧核糖核酸 phosphorothioation-based antiviral system in 古菌 Nature Communications, 2019, Apr 11;10(1):1688. doi: 10.1038/s41467-019-09390-9.
4.Cao B. #, Chen C. #, DeMott 多发性硬化症 #, Cheng Q., Clark T.A., Xiong X., Zheng X., Butty V., Levine S.S., Yuan G., Boitano M., Luong K., Song Y., Zhou X., Deng Z., Turner S.W., Korlach J., You D.*, Wang L.*, Chen S.*, Dedon P.C. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951.
5.Wang L, Chen S*, Vergin KL, Giovannoni SJ, Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC*. 脱氧核糖核酸 phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.
6.Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S*. Synthetic genomes: from 脱氧核糖核酸 synthesis to genome 设计 Angew Chemie Int Ed., 2018, 57: 2~11.
7.Wang L, Jiang S, Deng Z, Dedon P, Chen S*. DNA phosphorothioate modification – a new multi- functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036
8. Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S*, Yue Z*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy, 2019 Jul 30:1-15. doi: 10.1080/15548627.2019.1644076.
9. Chen Y., Deng Z, Jiang S., Hu Q., Liu H., Zhou S., Ma W., Chen S.*, Zhao Y*. Human cells lacking coilin and Cajal bodies areproficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277.
10. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.
11. Wang F#, Wang L#, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for 核糖核酸 targeting, tracking and editing. Biotechnology Advances, 2019, https://doi.org/10.1016/j.biotechadv.2019.03.016.
12. Deng Z, Purtell K Lachance V, Wold M, Chen S*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001.
13. Wu S#, Wang L# ; Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S*. Signature 砷 detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18.
14. Xia S, Chen J, Liu L, Wei Y, Deng Z, Wang L, Chen S*. Tight control of genomic phosphorothioate modification by the 巴西网球公开赛modulated autoregulation and reusability of DndB. Molecular Microbiology, 2019 April, 11(4): 938-950. doi: 10.1111/mmi.14186.
15. Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Chen S*, Zhao X*. Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity. Theranostics, 2018, 8(6): 1624~1635
16. Liu L, Zhang Y, Jiang D, Du S, Deng Z, Wang L, and Chen S*. Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications. Biotechnology Journal, 2019, 14, 1800001. DOI: 10.1002/biot.201800001.
17.Yan G, Chen X, Du S, Deng Z, Wang L, Chen S*. Genetic mechanisms of 砷 detoxification and
新陈代谢 in bacteria. Current Genetics, 2019, 65: 329–338, doi.org/10.1007/s00294-018-0894-9.
18. Chen S.*, Wang L., Deng Z*. Twenty years hunting for 硫 in 脱氧核糖核酸 Protein \u0026 Cell, 2010, 1(1): 14-21.
19. Wang L.#, Chen S.#, Xu T., Taghizadeh K., Wishnok J., Zhou X., You D., Deng Z, Dedon P. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology, 2007, 3(11): 709-710.
20. Chen S.#, Galan M. C.#, Carla Coltharp, O’Connor S. E. Redesign of a central enzyme in alkaloid biosynthesis. 化学 \u0026 Biology, 2006, 13(11): 1137-41.
21. Chen S, Huang X, Zhou X, Bai L, He J, Jeong KJ, Lee SY, Deng Z. Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. 化学 \u0026 Biology, 2003, 10(11): 1065-76.
22. Chen S.#, Mao X.#, Shen Y., Zhou Y., Li J., Wang L., Tao X., Yang L., Wang Y., Zhou X., Deng Z., Wei D. Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and Environmental Microbiology, 2009, 75(6): 1778-81.
陈实.武汉大学药学院.2022-03-09