更新时间：2024-09-21 03:09
张遵义，男，1957年生，兰州市人，博士，美国罗切斯特大学医学院转基因及基因打靶中心技术主任，2010年1月正式加盟杭州师范大学，杭州市第一批全球引才“521”计划，博士生导师。主要从事动物器官发育，首次发现遗传信号通路间的拮抗作用与哺乳纲形成特有的单排牙的齿列有关。这项结果不仅对牙发育机理的研究而且对牙的再生研究也有广泛的参考意义，主要结果2009年发表在Science上。
1978-1982年，西北师范大学生物系本科生
1982-1985年，福建师范大学实验胚胎学专业硕士研究生
1986-1995年，西北师范大学生物系，讲师、副教授
1995-1999年，挪威奥斯陆大学发育生物学专业博士研究生
1999-2004年，杜兰大学发育生物学博士后
2004-2005年，挪威奥斯陆大学，副教授
2006-2009年，美国罗切斯特大学，助理教授
2010年起，杭州师范大学生命科学院动物发育与胚胎干细胞研究所任PI
制备及利用遗传修饰模式小鼠研究头面部器官发生
研究方向：哺乳纲头面部器官发育及新生缺陷形成中的分子及遗传学机制
分子生物科学基础研究奖，Tulane大学健康研究，2000年
SIGMA XI 优秀博士后研究奖，Tulane大学健康研究，2001年
1999－2004 NIH R01，R01DE12329，博士后，为此课题的主要参与及完成者
2002－2004 NIH R01，R01DE14044, 博士后，重点执行该课题的研究
2003－2004 NIHR26，博士后，重点参与课题
2005－2007 NIH T32DE007202，NIH 训练基金获得者
Zhang, Z.Y., James, E., Balmer, A., L?vlie, A., Fromm, S.H. and Blomhoff, R. (1996). Specific teratogenic effects of Different Retinoic acid isomers and Analogs in the Developing Anterior Central Nervous system of zebrafish. Dev. Dyn. 206,73-86
Zhang, Z.Y., Yu, X.Y., Zhang, Y.D., Zhao, X., Hu, Y.P., Geronimo, B; L?vlie, A., Fromm, S.H. and Chen, Y.P (2000). Targeted expression of constitutively active BMP 捕手IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev. Biol. 220, 154-167.
Zhang, Y.D.*, Zhang, Z.Y.*, Zhao. X., Yu, X.Y., Hu, Y.P., Fromm, SH. and Chen, Y.P. (2000). A new 函数 of BMP4: BMP4 positively and negatively regulates Sonic 刺猬亚科 expression in the mouse tooth germ.. Development 127, 1431-1443. (*: equal first author)
Zhao, X.*, Zhang, Z.Y.*, Song, Y., Zhang, Y.D., Zhang, X., Hu, Y., Fromm, S.H, and Chen, Y.P. (2000). Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and BMP-2步兵战车 in the enamel knot of wild type tooth germ. Mech. Dev. 99, 29-38. (*: equal first author)
Zhang, Z.Y., Song, Y.Q., Zhao,X., Zhang, X.Y, Fermin. C. and Chen, Y.P. (2002). Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and SHH signaling in the regulation of mammalian palate development. Development 129, (17). 4135-3146.
Zhang, Z.Y., Zhang, X.Y., Song, Y.Q., Jones, T., Jones, S., Fermin, C. and Chen Y.P. (2003). The process brevlis (lateral processes) of malleus is dispensable for normal hearing in mice. Dev.Dyn 227, 69-77. (Corresponding author)
Zhang, Z.Y., Song Y.Q, Zhang X.Y. Tang J., Chen, J., and Chen, Y.P.(2003). Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech. Dev. 120, 1469-1479. (Corresponding author)
Alappat, S., Zhang, Z.Y., Chen,Y.P (2003). Msx Homeobox gene family and craniofacial development. Cell Research 13, 429-442.
Shusheng Wang, Xueyan Yu, Tao Zhang, Xiaoyun Zhang, Zunyi Zhang, and Yiping Chen (2004). CPCL2 regulates the left-right asymmetry by repressing SHH expression in Hensen’s Node. Development 131, 4381-4391.
Sylvia R. Alappat*, Zunyi Zhang*, Kenraro Suzuki, Xiaoyun Zhang, Rulang Jiang, Gen Yamada, and Yiping Chen. (2005). The cellular and molecular etiology of isolated cleft secondary palate in FGF10 mutant mice. Dev. Biol 277, 102-113. (* Equal first autors).
Hidenao Ogi, Kentaro Suzuki, Yukiko Ogino, Mika Kamimura, Mami, Miyado, Xu Ying, Zunyi Zhang, Masanori Shinohara, YiPing Chen and Gen Yamada (2005). The ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice. Anatomical Record 284A:424-430.
Ling Yu, Shuping Gu, Sylvia Alappat, Yiqiang Song, Mingqun Yan, Xiaoyun Zhang, Gouzhong Zhang, Yanding Zhang, Zunyi Zhang, and Yiping Chen (2005) Shox-2-deficient mice exhibit a rare type of incomplete cleft secondary palate. Development 132, 4397-406
Hilliard, A, Yu L, Gu, SP, Zhang ZY and Chen YP (2005). Regional regulation of palatal growth and patterning along the anterior–posterior axis in mice. J. Anat. 207, 655-667.
Yiqiang Song, Zunyi Zhang, Xueyan Yu, Minquan Yan, Xiaoyun Zhang, Shuping Gu, Thomas Stuart, Chao Liu, Jakob Reiser, Yanding Zhang, Yiping Chen (2006). Application of 慢病毒属mediated RNAi in studying gene function in mammalian tooth development. Dev Dyn 235,1347-1357. (*Equal first authors)
Yu Lan, Rosemary C. Ryan, Zunyi Zhang, Steven A. Bullard, Jeffrey O. Bush, Kathleen M. Maltby, Andrew C. Lidral, Rulang Jiang (2006). Expression of Wnt9b and activation of Canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn 235, 1448-1454
Zunyi Zhang, Yu Lan, Yang Chai, Rulang Jiang (2009). Antagonistic actions of Msx1 and? Osr2 Pattern Mammalian Teeth into Single Row. Science 323, 1232-1234
Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y.(2009). Hands is required in the epithelium for palatogenesis in mice. Dev. Biol. 330,131-141.