更新时间：2024-09-21 15:21
李卓玉，女，山西大学生命科学学院教授（二级），博士生导师。现任山西大学生命科学学院院长，党委副书记，山西大学生物技术研究所所长。李卓玉教授于2002.03在德国Kaiserslautern大学生物化学系，并获得理学博士学位，2003.09至2009.09进入邓迪大学生物医学中心从肿瘤病因及分子干预研究。在此期间主要聚焦在大肠癌Wnt信号通路、细胞骨架运动和肿瘤细胞的浸润等领域的研究。2009年秋全职回到山西大学工作，并于2010年入选“山西省海外引进百人计划”。
李卓玉教授课题组主要围绕结肠癌发病机理进行深入系统的研究，包括：肿瘤标靶分子的揭示及其外源分子干预、细胞周期与凋亡、细胞迁移和癌症转移、肿瘤信号传导、肿瘤免疫调控等；在分子、细胞、模式动物和人体标本等多个层次进行关键基因和蛋白的调控机制研究，为肿瘤的预防和治疗发现新型诊断/预后的分子标志物以及天然产物候选药物。
1997.04-2002.03 德国Kaiserslautern大学攻读博士学位
1993.09-1996.06 山西大学攻读在职硕士究生
1982.09-1986.06 山西大学攻读学士
2017年 山西大学生命科学学院院长
2009至2016年 山西大学生物技术研究所 所长
中国生物化学与分子生物学会山西省生物化学与分子生物学会理事
《中国细胞生物学学报》编辑
山西大学学报编委
2016年: 山西省高等学校科学技术成果奖自然科学类一等奖
2016年：中国产学研合作个人创新奖
2014年：全国优秀科技工作者
2014年：第六届“山西省十佳中青年优秀科技工作者”
2013年：第七届山西省优秀科技工作者
2013年：浙江省“钱江学者”
2013年：山西省“131”领军人才
2012年：山西省学术技术带头人
2010年：山西省“百人计划”海外引进人才
2010年: 山西省科技奉献奖“先进个人二等奖”（山西省科协）
（1）冬葵子活性蛋白的制备方法和应用：201410238318.3
（2）一种雷公菌抗肿瘤多糖及其制备方法和应用：201410459857.X
（3）一种普通念珠藻水应激蛋白基因及其重组蛋白的制备和应用: 2013-1-0291766.5
（4）一种胰蛋白酶抑制剂及其制备方法和应用：2012-1-0012186.3
（5）一种谷糠抗肿瘤活性蛋白及其制备方法和应用：2012-1-0084106
（6）一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用：2011-1-0313113.3
（7）力生长因子多肽及其制备方法和用途：2010-1-0224435.6
（8）一种植物源农药及其生产方法和应用：2010-1-0259258.5
1.Li Z*, Näthke IS.Tumor-associated NH2-terminal fragments are the most stable part of the Adenomatous Polyposis Coli protein and can be regulated by interactions with COOH-terminal domains, Cancer Research , 2005; 65 (12): 5195-5204. IF: 9.234
2.Zhuoyu Li*, Karin Kroboth, Ian P Newton, Inke S Nathke. Novel self-association of NH2-terminal regions of the Adenomatous polyposis coli protein regulates APC cluster formation and cell migration. Journal of Cell Science , 2008, 121: 1916-1925. IF: 6.290
3.Dina Dikovskaya, Zhuoyu Li*, Ian P Newton, Iain Davision, Paul Clacke and Inke S Nathke. Microtubule assmbly by the Apc protein is regulated by importin-β-RanGTP. Journal of Cell Scienc e. 2010, 123:1242-1253. IF: 6.290
4.Zhuoyu Li*, Wenling Li, Wensi Li, Li Song, Cilia. adenomatous polyposis coli and associated diseases. Oncogene . 2012, 31(12):1475-83. IF: 7.932
5.Zongwei Li, Zhuoyu Li*. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. 华晨宝马reviews on cancer .2012，1826(1):13-22．IF:8.8
6.Zongwei Li, peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. BBA-reviews on cancer . 2014, 24;1846(2):285-296. IF: 8.8
7.Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang,Peng Yang, Zhuoyu Li*. GRP78 enhances the glutamine metabolismto support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget . 2014, 30;5(14):5369-5380. IF: 6.6
8.Haili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu,Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li*. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget , 2016, 7 (47): 78069-78082. IF: 5.008
9.Xiaoting Jin, Meilan Chen, Ruijin Li,Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng, Zhuoyu Li*.Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of 毒理学 . 2016, 90 (8), 1929-38. IF: 6.637
10.Zongwei Li, Ming 壮族, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells, Scientific Reports . 2016,6,1-11. IF:5.228
11.Xiaoqin La, Lichao Zhang, Zhuoyu Li*, Peng Yang, Yingying Wang. 小檗碱induced autophagic cell 死亡 by elevating GRP78 levels in cancer cells. Oncotarget , 2017, doi:10.18632/oncotarget.14959. IF: 5.008
12.Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by 脂多糖 in colorectal cancer. Cellular Signalling . 2015, 27, 1525-1532. IF:4.471
13.Zongwei Li, YingyingWang, Ian P. Newton, Lichao Zhang, Pengyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ. Cellular Signalling . 2015, 27, 1237–1245. IF:4.471
14.Yingying Wang , Haili Wu, Zongwei Li, Peng Yang, Zhuoyu Li*. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Exp Cell Res . 2016, 351(1):24-35.IF: 3.378
15.Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li* and Zhuoyu Li*.Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. bmc Biotechnol . 2016; 16(1):65. IF: 2.452
16.Peng Yang#, Zongwei Li#*, Lichao Zhang, Hanqing Li, Zhuoyu Li*. Analysis of metabonomic profiling alterations in a mouse model of 结肠炎associated cancer and 2-deoxy-D-glucose treatment. RSC Advances . 2016, 6, 58862. IF: 3.814
17.Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage byvitamin c and 槲皮素 in human bronchial epithelial cells. Chemosphere .2016,144,459-466.IF:3.698
18.Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao M, Weiping Liu. DichlorodiphenyldichloroethyleneDichlorodi exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.Environ Toxicol . 2016, 29, 350-359.IF:2.868
19.Jiangying Shi, Shuhua Shan, Zongwei Li, Hanqing Li, Xinfeng Li, Zhuoyu Li*.Bound polyphenol from foxtail millet bran induces apoptosis in HCT-116 cell through ROS generation. Journal of functional foods. 2015, 17, 958-968.IF:3.973
20.Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via pi3k/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications . 2015, 459(2), 327-332. IF:2.371
21.Shuhua Shan, Jiangying Shi, Zhen Li,Huixiang Gao, Tonglin Shi, Zongwei Li, Zhuoyu Li*.Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. Food Funct . 2015, 8; 6(7): 2331-2338.IF:2.686
22.Min Guo, Guobin Ding, Songjia Guo, Zhuoyu Li*, Liangqi Zhao, Ke Li, Xiangrong Guo. Isolation and antitumor efficacy evaluation of a 多糖 from Nostoc commune Vauch. Food Funct . 2015, 6, 3035-3044. IF: 2.686
23.Tonglin Shi, Lichao Zhang, Zhuoyu Li*, Ian P Newton Quanbin Zhang. Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of 埃希氏菌属 coli.Protein Expr Purif .2015 Mar; 107:13-9. IF:1.407
24.Songjia Guo, ShuhuaShan,Xiaoting Jin,Zongwei Li, Zhuoyu Li*, LichaoZhao, Quan An, Wei Zhang. 液态水 Stress Proteins from Nostoc commune Vauch. Exhibit Anti-Colon cancer activities in Vitro and in vivoJ Agric Food Chem .2015 Jan 14;63(1):150-9.IF:2.857
25.Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li*, Zhuoyu Li*, Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion viaautocrine TGF-β/Smad2/3 signaling. Int J Biochem Cell Biol . 2015, 2015, 64, 202-211. IF:3.905
26.Li Song, Meirong Zhao, Jianxin Liu, Zhuoyu Li*,Hong Xiao, Weiping Liu. p, p’-Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through pi3k/AKT and 刺猬亚科/Gli1 signaling pathways. Toxicology Research . 2015, 4, 1214–1224. IF:2.161
27.Li Song, Zhuoyu Li*, Wei-Ping Liu, Mei-Rong Zhao. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biology \u0026 Therapy . 2015, 16, 1–7. IF:2.921
28.Li Song, Jiao Chang and Zhuoyu Li*.A serine protease extracted from 栝楼属 kirilowii induces apoptosis via the PI3K/AKTmediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food\u0026 Function .2016, 7(2):843-54.IF:2.686
29.Tonglin Shi, Zongwei Li, Quanbin Zhang, Dawen Zheng and Zhuoyu Li*. Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model.Pak J Pharm Sci.2015,28,1997-1999.IF:0.581
30.Tonglin Shi,Cao Zhao Zhuoyu Li*,Quanbin Zhang,Xiaoting Jin. Bisphenol a exposure promote the migration of NCM460 cells via estrogen 捕手mediated integrin β1/MMP-9 pathway.Environ Toxicol .2014 2016 Jul;31(7):799-807 .IF:2.868
31.Li Song, Jianxin Liu, Zhuoyu Li*, 2016 Jul;31(7):799-807Meirong Zhao, Weiping Liu. P’-dichlorodiphenyl-dichloroethylene induces colorectal Adenocarcinoma Cell Proliferation through Oxidative Stress.PLoS One . 2014, 11;9(11):e112700.IF:3.057
32.Shuhua Shan, Zongwei Li, Songjia Guo, Zhuoyu Li*, Tonglin Shi, Jiangying Shi. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer. Journal of functional foods . 2014, 10:444-455.IF:3.973
33.Li song, Junyu Zhao, Xiaotiing Jin, Zhuoyu Li*, Ian P Newton, Weiping Liu, Hong xiao, Meirong Zhao. The organochlorine p,p'- dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling. Toxicol Lett . 2014, 17; 229(1):284-91. IF:3.522
34.Li Song, Yuxin Jia, Wensi Zhu, Ian P Newton, Zhuoyu Li*, Wenlin Li. N-terminal trunctions of adenomatous polyposis coli are associated with primary cilia defects. Int J Biochem Cell Biol . 2014, 21; 55C:79-86.IF:3.905
35.Yanan Peng, Zongwei li, Peng Yang, Ian P Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. Biochem Biophys Res Commun . 2014, 15; 451(1):68-73.IF:2.371
36.Haili wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng fan, Zhuoyu Li*. PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells. Cell Signal . 2014, 26(11):2397-405. IF:4.191
37.Xaioting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-滴滴涕 exposure on cell adhesion of hepatocellular carcinoma. 毒理学 . 2014, 322:99-108.IF:3.817
38.Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular. Toxicology letters . 2014, 225:158-166. IF:3.522
39.Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilites colon cancer migration via the modulation of STAT3 signaling. Cell Signal . 2014, 26(9):1853-1862.IF:4.191
40.Shuahua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li*, Maolin Guo. A novel protein extraxted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. Toxicology letters . 2014, 227:129-138.IF:3.522
41.Zongwei Li, Lichao Zhang, Hanqing Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Rep. 2014, 47(8):445-450.IF:2.782
42.Zongwei Li, Chao Zhao, Zhuoyu Li * , Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo Li. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol .2014, 47, 68-75. IF:3.905
43.Xiaoting Jin, Li Song, Xiangyuan Liu, Meilian Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p’ -滴滴涕induced cytotoxicity via the ROS–mediated mitochondrial pathway and NFkB/FasL pathway. PLoS One . 2014, 9(12):e113257. IF:3.057
44.Yanan Peng, Zongwei Li, Zhuoyu Li*. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer associated fibroblasts. Biochemical and Biophysical Research Communications . 2013, 440(4):558-63.IF:2.371
45.Zongwei Li, Lichao Zhang,Yarui Zhao,Hanqing Li,Hong Xiao,Rong Fu, Zhuoyu Li*. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion.Int J Biochem Cell Bi奥林匹克里昂足球俱乐部2013, 45(5):987-994.IF:3.905
46.Cui Wang, Zhuoyu Li*, Quan Zhang, Meirong Zhao, Weipiing Liu. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chairality in risk assessment of POPs metabolisms. Environ Sci Technol . 2013, 6; 47(8):3909-3917. IF:5.393
47.Scott A Nelson, Zhuoyu Li*, Ian P Newton，David Schiffmann，Cornelis J. Weijer，Paul L. Appleton，Inke S. N?thke. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Disease Models \u0026 Mechanisms . 2012, 5(5):1-7. IF:4.316
48.Lixi Niu, Chenyun Guo, Jingming Yuan, Zhuoyu Li*. Potential roles of recombinant 乙酰胆碱 捕手 α subunit 1-211 in immunoadsorbent and 脱氧核糖核酸 immunization.J Immunol Methods. 2011, 30; 372(1-2):14-21. IF:1.858
首页 » 师资队伍 » 生物工程系.山西大学生命科学学院.2017-10-03
研究人员.山西大学生物技术研究所.2017-10-03