更新时间：2024-09-20 21:29
邵峰（1972年1月-）是一位中国生物制药化学家和免疫学家。他出生于淮安市，并在北京大学和密歇根大学接受教育。邵峰是中国科学院院士，目前担任北京生命科学研究所的学术副所长和资深研究员。他还是第十四届全国政协委员。 邵峰的研究主要集中在病原菌和宿主相互作用的机理上。他在病原菌毒力机制和抗细菌天然免疫领域取得了一系列重要的原创性发现。他的团队发现了识别细菌鞭毛蛋白和两种感知蛋白的方法，这些蛋白分别针对内毒素和某一类细菌外毒素，为研制一些细菌新型冠状病毒疫苗奠定了基础。此外，他还发现了一种重要的促使细胞炎性坏死的蛋白，可应用于败血症的治疗。 邵峰的研究成果获得了广泛的认可和奖励。2012年，邵峰获得国家杰出青年科学基金资助。他曾获得霍华德·休斯医学研究所国际青年科学家奖、鄂文·西格青年科学家奖以及2019年未来科学大奖的“生命科学”奖。2022年，他因在细胞焦亡（pyroptosis）领域的原创科学发现而获得纽约癌症研究所授予的威廉·柯利奖。 邵峰的研究对于理解病原菌和宿主相互作用的机制以及开发新的治疗方法具有重要意义。他的贡献使他成为中国科学界的杰出科学家之一。
2023年9月2日，获得2022年度陈嘉庚科学奖生命科学奖。
1980年，在流均镇读完小学、初中（至1988年）。1988年，就读于江苏省淮安中学高中部（至1991年）。
1996年，毕业于北京大学中国科学技术大学物理系应用化学。
1999年，获得中国科学院生物物理研究所硕士学位。
2003年，获得密歇根大学医学院博士学位，之后进入加利福尼亚大学圣迭戈分校医学院进行博士后研究工作（至2004年）。
2004年，进入哈佛大学医学院进行博士后研究工作（至2005年）。
2005年，回国后进入北京生命科学研究所工作，建立实验室，开始独立研究生涯，先后担任研究员（2005年-2009年）、高级研究员（2009年-2012年）、资深研究员（2012年-）。
2011年12月，获得第五届药明康德生命化学研究奖。
2012年，获得国家杰出青年科学基金资助。同年获得美国霍华德·休斯医学研究所国际青年科学家奖（首届）。
2013年，入选首届“北京学者”和国家百千万人才工程。同年作为首位大陆本土科学家获得国际蛋白质学会颁发的鄂文·西格青年科学家奖。
2014年，入选国家创新人才推进计划（中青年科技创新领军人才）。
2015年5月，入选embo（EMBO）外籍成员。12月7日，当选中国科学院生命科学和医学学部院士。
2016年10月，获得何梁何利基金奖，同年被选为美国微生物学院会士（Fellow），同年入选第二批国家高层次人才特殊支持计划领军人才。
2019年当选为利奥波第那科学院院士；9月7日，2019未来科学大奖在北京公布，北京生命科学研究所学术副所长邵峰因其发现人体细胞内对病原菌内毒素LPS炎症反应的受体和执行蛋白的贡献获得“生命科学奖”；9月21日，2019年度求是杰出科学家奖颁奖典礼在北京清华大学蒙民伟音乐厅举行；中国科学院星院士、北京生命科学研究所研究员邵峰获得2019年度“求是杰出科学家奖”。
科研综述
邵峰实验室的研究集中在病原细菌感染宿主和宿主先天性免疫防御的分子机制。对于细菌感染来说，通过特殊的分泌系统向宿主细胞中注入毒素效应蛋白是病原细菌普遍采用的重要致病机制。这些效应蛋白往往以非常有效的方式作用于宿主信号转导中的关键分子，使其发生功能紊乱。效应蛋白的作用有利于细菌在宿主中的生存和进一步感染。研究以多种临床上常见的病原菌（志贺氏菌属, 沙门氏菌属, Enteropathogenic E. coli, Legionella 以及伯克霍尔德菌）为模式，着眼于发现并揭示效应蛋白在抑制真核生物重要信号转导通路中的一些新的、较为普遍的生物化学机制。
邵峰实验室的研究工作在这方面取得了一系列的突破和发现。①来源于Shigella，Salmonella和植物假单胞菌感染的OspF家族三型分泌系统效应蛋白通过一种崭新的磷酸化Thr裂合酶的活性，特异性地、不可逆地“去磷酸化”宿主MAPK激酶并使其失活，从而抑制宿主细胞因子的表达。②Legionella的四型分泌系统效应蛋白LegK1能模拟宿主中的IKK激酶而磷酸化IκBa蛋白，并诱导其被泛素化和降解，进而激活NF-κB通路并对巨噬细胞凋亡产生抑制作用。③三型分泌系统效应蛋白CHBP（伯克霍尔德菌）和Cif（EnteropathoGen.Gic E. coli）特异性地修饰（脱氨）泛素和泛素样蛋白NEDD8中Gln-40。这种修饰能有效地阻断宿主泛素-蛋白酶体通路并导致诸如细胞周期等重要细胞生理过程发生功能紊乱。
邵峰团队认为，这些研究不仅对理解感染和致病的分子机理有极大的促进作用，更为重要的是，由于病原细菌和宿主(人类)长期共同进化，其分泌的毒素效应蛋白也为邵峰团队研究真核生物本身的信号转导机制提供了独特的、前所未有的视角和研究工具。同时，邵峰团队也对宿主巨噬细胞如何通过其先天性免疫系统来拮抗病原微生物感染的机制感兴趣。在受到感染后，巨噬细胞能感受到多种来自病原菌或其它病原微生物的一些模式分子，从而激活一类被称为炎症小体的蛋白复合物，同时发生炎症性细胞坏死和分泌白介素1b。炎症小体利用一类叫作NOD-like的受体分子感受来自病原菌的信号，但除此之外人们对炎症小体的组装和其上游的信号转导机制了解甚少。邵峰团队将结合生物化学、细胞生物学以及小鼠遗传学等多种手段来研究和阐明炎症小体被激活的生化机制。
学术论著
截至2015年，邵峰实验室已发表论文50多篇，被国际同行引用4000多次，他以通讯作者身份在《自然》《科学》《细胞》等三大国际顶级学术期刊上发表论文9篇，研究成果多次被专家和学术杂志重点评述。
1. Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen L, Han W, Shen L, Ding J, Shao F.(2020) Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science, 368, 6494.
2. Wang Q, Wang Y, Ding J, Wang C, Zhou X, Gao W, Huang H, Shao F, Liu Z.(2020) A bioorthogonal system reveals antitumour immune 函数 of pyroptosis. Nature, 579,421-426.
3. Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, Li Z, Wang Y, Zhao Q, Shao F, Ding J.(2020) Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. 细胞, 2020,180, 941-955.
4. Xu Y, Zhou P, 成姓 S, Lu Q, Nowak K, Hopp A, Li L, Shi X, Zhou Z, Gao W, Li D, He H, Liu X, Ding J, Hottiger M, Shao F. (2019) A Bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy, Cell, 178, 1-15.
5. Zhou P, She Y, 越南盾 N, Li P, He H, Borio A, Wu Q, Lu S, Ding X, Cao Y, Xu Y, Gao W, Dong M, Ding J, Wang DC, Zamyatina A, Shao F. (2018) Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose, Nature, 561, 122-126 (Published online Aug 15).
6. Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, Xu J, Xu B, Wang F \u0026 Shao F. (2017) Ubiquitination and degradation of GBPs by a 志贺氏菌属 effector to suppress 宿主 defense, Nature, 551, 378-383 (Published online Oct 11).
7. Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K \u0026 Shao F. (2017) Chemotherapy drugs induce pyroptosis through caspase-3 CLEAVAGE of a Gasdermin, Nature, 547 (7661), 99-103 (Published online May 01).
8. Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC \u0026 Shao F. (2016) Pore-forming activity and structural auto性抑制 of the Gasdermin family, Nature (Article), 535 (7610), 111-116 (Published online 08 June 2016).
9. Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, 壮族 Y, Cai T, Wang F \u0026 Shao F. (2015) CLEAVAGE of GSDMD by inflammatory caspases determines pyroptotic 细胞 死亡, Nature (Article), 526, 660–665.
10. Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-日产汽车公司 G, Zamyatina A, Liu X, Chen S \u0026 Shao F. (2014) An 铁containing dodecameric heptosyltransferase family modifies bacterial autotransporters in 病程, 细胞 宿主 \u0026 Microbe, 16, 351–363.
11. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L \u0026 Shao F. (2014) Inflammatory caspases are innate immune receptors for intracellular LPS, Nature (Article), 514, 187-192 (Published online 06 August 2014).
12. Xu H, Yang J, Gao W, Li L, Li P, Zhang L, GONG YN, peng X, Xi JJ, Chen S, Wang F, Shao F. (2014) Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature, 513, 237–241 (Published online 11 June 2014).
13. Li S, Zhang L, Yao Q, Li L, 越南盾 N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S \u0026 Shao F. (2013) Pathogen blocks 宿主 死亡 捕手 信令 by arginine GlcNAcylation of death domains. Nature, 501, 242-246.
14. Yang J, Zhao Y, Shi J \u0026 Shao F. (2013) Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc. N亚特兰大老鹰 Acad. Sci., 110, 14408-13.
15. Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F. (2012) Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract 宿主 defenses. 细胞, 150, 1029-41.
16. Zhang L, Ding X, Cui J, Xu H, Chen J, Gong YN, Hu L, Zhou Y, Ge J, Lu Q, Liu L, Chen S, Shao F. (2012) Cysteine methylation disrupts ubiquitin-chain sensing in NFkB activation. Nature, 481, 204-8.
17. Zhao Y, Yang J, Shi J, GONG YN, Lu Q, Xu H, Liu L, Shao F. (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature, 477, 596–600.
18. Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F. (2010) Glutamine deamidation and dys函数 of ubiquitin/NEDD8 induced by a bacterial effector family. Science, 329, 1215-8.
19. Li H, Xu H, Zhou Y, Zhang J, Long C, Li S, Chen S, Zhou JM, 邵姓 F. (2007) The phosphothreonine lyase activity of a bacterial type III effector family. Science, 315, 1000-3.
Other Publications:
Research articles:
1. Zhang C, Song J, Huang H, Fan X, Huang L, Deng J, Tu B, Wang K, Li J, Zhou M, Yang C, Zhao Q, Yang T, Wang L, Zhang J, Xu R, Jiao Y, Shi M, Shao F, Sékaly R, Wang F (2020) NLRP3 inflammasome induces CD4+ T 细胞 loss in chronically HIV-1–infected patients, The Journal of Clinical Investigation, 131 (6).
2. Karmakar M, Minns M, Greenberg E, Diaz-Aponte J, Pestonjamasp K, Johnson J, Rathkey J, Abbott D, Wang K, Shao F, Catz S, Dubyak G, Pearlman E (2020) N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of 等离子体 membrane pores and pyroptosis, Nature communications, 11, 1-14.
3. Xu H, Shi J, Gao H, Liu Y, Yang Z, Shao F, 越南盾 N. (2019) The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by 炭疽病 lethal toxin, The EMBO journal, 38, e101996.
4. Ji C, Du S, Li P, Zhu Q, Yang X, Long C, Yu J, Shao F, Xiao J. (2019) Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9. 8, PLoS 病原体, 15, e1007876.
5. Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover S, Zhang X, Li L, Xiang B, Shi J, Li X, Daugherty A, Smyth S, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y, Li Z. (2019) Inflammasome activation triggers blood clotting and 宿主 死亡 through pyroptosis, 免疫力, 50, 1401-1411.
6. Ding J, pan X, Du L, Yao Q, Xue J, Yao H, Wang D, Li S, Shao F. (2019) Structural and 函数al insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector, Molecular 细胞, 74, 1-14.
7. Rathinam V, Zhao Y, Shao F. (2019) Innate 免疫力 to intracellular LPS, Nature Immunology, 20, 527-533.
8. Xu H, Shi J, Gao H, Liu Y, Yang Z, Shao F, 越南盾 N. (2019) The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by 炭疽病 lethal toxin, embo, 38(13):e101996.
9. Liu W, Zhou Y, peng T, Zhou P, Ding X, Li Z, Chen S, Hang HC, and Shao F. (2018) N-fatty acylation of 倍数 membrane-associated proteins by Shigella IcsB effector to modulate 宿主 function, Nature Microbiology, 3, 996工作制1009.
10. Adanitsch F, Shi J, Shao F, Beyaert R, Heine H, and Zamyatina A. (2018) Synthetic glycan-based TLR4 agonists targeting Caspase-4/11 for the development of adjuvants and immunotherapeutics, Chem. Sci., 9, 3957-3963.
11. Yang J, Zhao Y, Li P, Yang Y, Zhang E, Zhong M, Li Y, Zhou D, Cao Y, Lu M, Shao F#, Yan H#. (2018) 序列 determinants of specific pattern-recognition of bacterial ligands by the NAIP-NLRC4 inflammasome, 细胞 Discovery,4: 22. doi: 10.1038/s41421-018-0018-1 (# corresponding authors).
12. Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi X, Tang N, Shao F, Luo M. (2018). A hybridization-chain-reaction-based method for amplifying immunosignals, Nature Methods, 15, 275-278.
13. Xu B, Jiang M, Chu Y, Wang W, Chen D, Li X, Zhang Z, Zhang D, Fan D, Nie Y, 邵姓 F, Wu K, Liang J. (2018) Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice, J Hepatol., 68, 773-782.
14. Zhou Y, Huang C, Yin L, Wan M, Wang X, Li L, Liu Y, Wang Z, Fu P, Zhang N, Chen S, Liu X, Shao F, Zhu Y. (2017). N-Fatty acylation of Rho GTPases by a MARTX 毒素 effector, Science. 358, 528-531.
15. Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H, Wang C, Wang H, Hui L, Du C, Xie X, Zeng R, Lin A, Shi D, Ruan K, Yan J, Gao GF, Shao F, Hu R. (2017) Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK, PLoS Pathogen,13(7): e1006534.
16. Litvak Y, Sharon S, Hyams M, Zhang L, Kobi S, Katsowich N, Dishon S, Nussbaum G, Dong N, Shao F, and Rosenshine I. (2017) Epithelial 细胞s detect 泛函 type III secretion system of enteropathogenic 埃希氏菌属 coli through a novel NF-κB signaling 神经通路 PLoS Pathogen, 13(7): e1006472.
17. Dong N, Niu M, Hu L, Yao Q, Zhou R, and Shao F. (2016) Modulation of membrane phosphoinositide 动力学 by the phosphatidylinositide 4-kinase activity of the Legionella LepB effector, Nature Microbiology, 2:16236.
18. Thurston TL, Matthews SA, Jennings E, Alix E, Shao F, Shenoy AR, Birrell MA, Holden DW. (2016) Growth inhibition of cytosolic 沙门氏菌属 by caspas新干线E1系电力动车组 and caspase-11 precedes 宿主 cell 死亡, Nature Communications, 7:13292.
19. Gao W, Yang J, Liu W, Wang Y, Shao F. (2016) Site-specific phosphorylation and microtubule 动力学 监察 Pyrin inflammasome activation, Proc. Natl. Acad. Sci., 113, E4857-66.
20. Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, 邵姓 F, Yao YF (2016) Reversible lysine acetylation is involved in 脱氧核糖核酸 DNA复制 initiation by regulating activities of 引发剂 DnaA in 埃希氏菌属 coli, Sci Rep., 6: 30837.
21. Aubert DF, Xu H, Yang J, Gao W, Li L, Chen S, Valvano MA, Shao F. (2016) A 伯克霍尔德菌 type VI effector deamidates Rho GTPases to activate the Pyrin inflammasome, Cell 宿主 \u0026 Microbe, 19, 664-674.
22. Zhao Y, Shi J, Shi X, Wang Y, Wang F \u0026 Shao F. (2016) Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in 鼠科, Journal of Experimental 药品, 213(5), 647-56.
23. Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. (2016) An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells, Science, 352(6290), 1232-6.
24. Hu Z, Zhou Q, Zhang C, Fan S, 成姓 W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J. (2015) Structural and biochemical basis for induced self-propagation of NLRC4, Science, 350, 399-404.
25. Lu Q, Xu Y, Yao Q, Niu M and Shao F. (2015) A polar-localized iron-binding protein determines the polar targeting of 伯克霍尔德菌 BimA autotransporter and actin tail formation, Cellular Microbiology, 17, 408–424.
26. Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, Li L, Karar J, peng H, Chen S, Huang N, Rauscher FJ, Shao F. (2014) Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human 脱氧核糖核酸 Repair 神经通路 PLoS 病原体, 10: e1004522.
27. Yao Q, Lu Q, Wan X, Song F, Xu Y, Zamyatina A, Huang N, Zhu P \u0026 Shao F. (2014) A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family, eLife, 3: e03714.
28. pan M, Li S, Li X, 邵姓 F, Liu L and Hu HG (2014) Synthesis and Specific Antibody Generation of Glycopeptides with Arginine N-GlcNAcylation. Angew Chem Int Ed Engl., 53, 14517-14521 (co-corresponding author).
29. Ding J, Luo AF, Hu L, Wang DC, 邵姓 F. (2014) Structural basis of the ultrasensitive 钙质 indicator GCaMP6. SCIENCE CHINA Life Sciences, 57, 269–274.
30. Li T, Lu Q, Wang G, Xu H, Huang H, Cai T, Kan B, Ge J \u0026 Shao F. (2013) SET-domain bacterial effectors target 异染色质 protein 1 to activate 宿主 r脱氧核糖核酸 transcription. embo Reports, 14, 733-40.
31. Yu Q, Hu L, Yao Q, Zhu Y, 越南盾 N, Wang DC, Shao F. (2013) Structural analyses of a Legionella RabGAP effector reveal a new GAP fold that 催化ally mimics eukaryotic RasGAP. 细胞 Research, 23, 775-87.
32. Zhou Y, Dong N, Hu L, Shao F. (2013) The 志贺氏菌属 Type Three Secretion System Effector OspG Directly and Specifically Binds to 宿主 Ubiquitin for Activation. PLoS One, 8: e57558.
33. Yao Q, Cui J, Wang J, Li T, Wan X, Luo T, Gong YN, Xu Y, Huang N, Shao F. (2012) Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosIS系列坦克 Proc. Natl. Acad. Sci., 109, 20395-400.
34. Ku B, Lee KH, Park WS, Yang CS, Ge J, Lee SG, Cha SS, 邵姓 F, Heo WD, Jung JU, Oh BH (2012) VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathogen, 8: e1003082.
35. Ge J, Gong YN, Xu Y, Shao F. (2012) Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc. Natl. Acad. Sci., 109, 6193-8.
36. He S, Liang Y, Shao F, Wang X. (2011) Toll-like receptors activate programmed necrosis in macrophages through a 捕手interacting 激酶3–mediated 神经通路. Proc. Natl. Acad. Sci., 108, 20054-9.
37. Li C, Tu S, Wen S, Li S, Chang J, Shao F, and Lei X. (2011) Total Synthesis of the G2/M DNA Damage Check Point软件技术公司 Inhibitor Psilostachyin C. The Journal of Organic 化学, 76, 3566-70.
38. Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F. (2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research, 20, 1289-305.
39. Dong N, Liu L, Shao F. (2010) A bacterial effector targets 宿主 DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. The EMBO J., 29, 1363-76.
40. Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F. (2010) Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector sidM/DrrA. Proc. Natl. Acad. Sci., 107, 4699-704.
41. Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F. (2009) A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors. Proc. Natl. Acad. Sci., 106, 13725-30.
42. Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, peng, HB, Shao F. (2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to 监察 actin 细胞骨架 structure and 细胞 movement. 摩尔 Cell, 35, 841-55.
43. Dowen RH, Engel JL, 邵姓 F, Ecker JR, Dixon JE. (2009) A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to 等离子体 membranes. J. Biol. Chem., 284, 15867-79.
44. Yao Q, Cui J, Zhu Y, Wang G, Hu L, Long C, Cao, R, Liu X, Huang N, Chen S, Liu L, Shao F. (2009) A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the 宿主 细胞 cycle. Proc. Natl. Acad. Sci., 106, 3716-21.
45. Zhu Y., Li H., Hu L., Wang, J., Zhou Y., Pang Z., Liu L., Shao F. (2008) Structure of a 志贺氏菌属 effector reveals a new class of ubiquitin ligases. Nature Structural \u0026 Molecular Biology, 15, 1302-8.
46. Zhu Y, Li H, Long C, Hu L, Xu H, Liu L, Chen S, Wang DC, 邵姓 F. (2007) Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. 摩尔 Cell, 28, 899-913.
47. Zhang J, Shao F, Li Y, Cui H, Chen L, Li H, Zou Y, Long C , 蓝姓 L, Chai J, Chen S, Tang X, Zhou JM. (2007) A 假单胞菌属 syringae effector inactivates MAPKs to suppress PAMP-induced 免疫力 Cell 宿主 \u0026 Microbe, 1, 175-85.
48. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo, SM, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. (2006) Identification of a bacterial type III effector family with G-protein mimicry functions. Cell, 124, 133-45.
49. Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeska AB, Shao F, Yu V, Kwok R, Opipari AW, Jr., Castle VP. (2006) 信令 from p53 to NF-kappaB determines chemotherapy responsiveness of neuroblastoma. Neoplasia, 8, 964-74.
50. Zhu M, 邵姓 F, Innes RW, Dixon JE, Xu Z. (2004) The 晶体 structure of 假单胞菌属 avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc. Natl. Acad. Sci., 101, 302-7.
51. Shao F, Golstein, C, Ade J, Stoutemyer M., Dixon JE, Innes RW. (2003) Cleavage of Arabidopsis pbs1 by a bacterial type III effector. Science, 301, 1230-3.
52. Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. (2003) Biochemical characterization of the YersiniaYopT protease: cleavage site and recognition elements in Rho GTPases. Proc. Natl. Acad. Sci., 100, 904-9.
53. 邵姓 F, Merritt PM, Bao Z, Innes RW, Dixon JE. (2002) A 耶尔森菌属 effector and a 假单胞菌属 avirulence protein define a family of cysteine proteases functioning in bacterial 病程 细胞, 109, 575-88.
54. Bian X, McAllister-Lucas LM, Shao F, Schumacher KR, Feng Z, Porter AG, castle VP, Opipari AW, Jr. (2001) NF-kappa B activation mediates doxorubicin-induced cell 死亡 in N-type neuroblastoma cells. J. Biol. Chem., 276, 48921-9.
55. Shao F, Bader MW, Jakob U, Bardwell JC. (2000) DsbG, a protein disulfide isomerase with chaperone activity. J. Biol. Chem., 275, 13349-52.
56. Wang CG, He XL, Shao F, Liu W, Ling MH, Wang DC, Chi CW. (2001) Molecular characterization of an anti-epilepsy peptide from the 蝎子 Buthus martensi Karsch. Eur. J. Biochem., 268, 2480-5.
57. Shao F, Hu Z, Xiong YM, Huang QZ, Wang CG, Zhu RH, Wang DC. (1999) A new antifungal peptide from the seeds of Phytolacca americana: characterization, amino acid sequence and cDNA cloning. Biochim. Biophys. Acta, 1430, 262-8.
58. Shao F, Xiong YM, Zhu RH, Ling M, Chi CW, Wang DC. (1999) Expression and purification of the BmK M1 neurotoxin from the 蝎子 Buthus martensii Karsch. Protein Expr. Purif., 17, 358-65.
a) Invited review articles:
59. 弗朗茨·舒伯特 KA, Xu Y, Shao F, Auerbuch V. (2020) The 耶尔森菌属 Type III Secretion System as a Tool for Studying Cytosolic Innate Immune Surveillance, Annual Review of Microbiology, 74, 221-245.
60. Broz P, Pelegrín P, Shao F (2020) The gasdermins, a protein family executing cell 死亡 and inflammation, Nature 商品评价 Immunology, 20,143-157
61. Ding J, Shao F. (2018) Growing a gasdermin pore in membranes of pyroptotic cells. The embo J., 37(15). pii: e100067.
62. Dong N, Shao F. (2019) 摩尔ecular mechanism and immunological function of pyroptosis, SCIENTIA SINICA, 49, 小行星16061634
63. Basler M, Shao F. (2018) Bacterial infection and symbiosis. Mol Biol 细胞 29 (6), 683-684.
64. Galluzzi L, ¼, Shao F, ¼, Kroemer, G. (2018) 摩尔ecular mechanisms of cell 死亡: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death \u0026 Differentiation, 25 (3), 486-541.
65. Schroder K, Kanneganti TD, Shao F, Broz P. (2018) Mechanisms of Inflammasome Activation. J Mol Biol., 430 (2), 131-132.
66. Ding J, Shao F. (2017) snapshot: The NonCanonical Inflammasome, Cell, 168:544-544.新干线E1系电力动车组
67. Shi J, Gao W, Shao F. (2017) Pyroptosis: Gasdermin-mediated programmed necrotic cell 死亡, Trends in Biochemical Sciences, 42 (4), 245–254.
68. Zhao Y, Shao F. (2016) Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence, Current Opinion in Microbiology, 29, 37-42.
69. Lu Q, Li Shan, Shao F. (2015) Sweet talk: protein glycosylation in bacterial interaction with the 宿主. Trends in Microbiology, 23, 630-41 (Cover article).
70. Zhao Y, Shao F. (2015) The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus. Immunological 商品评价, 265, 85-102.
71. Yang J, Zhao Y, Shao F. (2015) Non-canonical activation of inflammatory caspases by cytosolic LPS in innate 免疫力 Current Opinion in Immunology, 32, 78–83.
72. Yang J, Xu H, Shao F. (2014) The immunological function of familial Mediterranean fever disease protein Pyrin. SCIENCE CHINA Life Sciences, 57, 1156-1161.
73. Zhao Y, Shao F. (2012) NLRC5: a NOD-like receptor protein with many faces in immune regulation. Cell Research, 22, 1099-101.
74. Gong YN, Shao F. (2012) Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation. Protein \u0026 Cell, 3, 98-105.
75. Ge J, Shao F. (2011) Manipulation of host vesicular trafficking and innate immune defense by Legionella Dot/Icm effectors. 细胞 Microbiol., 13, 1870-80.
76. Cui J, Shao F. (2011) 生物化学 and cell signaling taught by bacterial effectors. Trends in Biochemical Sciences, 36, 532-40.
77. Shao F. (2008) Biochemical functions of 耶尔森菌属 type III effectors. Current Opinion in Microbiology, 11, 21-9.
78. Juris SJ, Shao F, Dixon JE. (2002) Yersinia effectors target mammalian signaling pathways. 细胞 Microbiol., 4, 201-11 (Co-first author).
2016年邵峰作为校友在北京大学毕业典礼致辞上说：抓住事物的本质，排除干扰，做最简单合理的推断，你们就更有可能做出正确的选择和决定。事实上，最简单的、最纯粹的往往才是最深刻的，也是最持久永恒的。
邵峰一直秉持的原则是“招了学生就要对他们负责”，因此邵峰实验室每年只招两名学生，控制数量是为了保证质量，他最不能忍受的是学生没有明确的目标，搞不清楚要做些什么。
邵峰研究病原菌和宿主相互作用机理，在致病菌毒力机制、抗细菌天然免疫及细胞焦亡方向均取得系列重要原创性发现。（2017年中国细胞生物学学会杰出成就奖评）
邵峰对于病原菌感染和巨噬细胞免疫防御的生物化学机制研究有重要贡献。（2011年药明康德生命化学研究奖评）
邵峰通过研究致病细菌如何通过调节宿主细胞的多层信号通路而逃避其免疫反应的机理，获得了几个关键的科学发现。（人民网股份有限公司评）
邵峰为北京生命科学研究所学术副所长，资深研究员，主要从事病原菌和宿主相互作用的机理研究，在病原菌毒力机制和抗细菌天然免疫领域取得系列重要原创性发现。（2019年未来科学大奖生命科学奖评）
2012国家杰青基金建议资助名单公布.科学网.2024-05-30
13位科学家获颁2022年度陈嘉庚科学奖、青年科学奖.今日头条-中国科学报.2023-09-05
北京市科学技术委员会、中关村科技园区管理委员会 突出贡献中关村奖 邵峰.北京市科学技术委员会.2022-02-17
邵峰等四位科学家获2019未来科学大奖.www.chinanews.com.2019-09-08
2019年“求是奖”揭晓.news.sciencenet.cn.2019-09-22
邵峰 博士 - 科学研究 - 北京生命科学研究所.北京生命科学研究所.2021-12-09
第二届全国创新争先奖.科技人物.2020-06-05
2022年陈嘉庚科学奖、陈嘉庚青年科学奖有效候选人名单公布，四川这些人入围.今日头条.2021-08-19
对话邵峰院士：我的难处是要不断鼓励和说服学生.科学网.2021-09-26
关于公布2022年度陈嘉庚科学奖获奖项目和陈嘉庚青年科学奖获奖人名单的公告.今日头条-中科院之声.2022-12-22
2019未来科学大奖公布：邵峰获生命科学奖|科学奖|生命科学奖|未来科学大奖_新浪科技_新浪网.新浪网.2022-02-17