李太生 :北京协和医院感染内科主任

更新时间:2023-08-15 17:36

李太生,男,1963年出生。毕业于北京协和医学院,现任北京协和医院感染内科主任,北京协和医院艾滋病诊疗中心主任,清华大学医学院特聘教授。中华医学会感染病学分会候任主任委员兼艾滋病学组组长,中国医学科学院艾滋病中心副主任。擅长感染性疾病的诊治。2020年11月荣获2020年全国先进工作者荣誉称号。

人物经历

教育经历

1979年09月-1984年08月,在广州中山医学院医疗系本科毕业,获医学学士学位。

1987年09月-1990年02月,在北京协和医科大学内科学学系研究生毕业,获医学硕士学位。

1995年12月-1999年01月,在法国高等应用研究院地球与生命科学系,获免疫学博士学位。

工作经历

1984年09月-1990年12月,北京协和医院内科住院医师,总住院医师。

1990年12月-1993年10月,北京协和医院内科感染内科主治医师

1993年10月-1995年12月,国家教育部公派赴巴黎Pitie-Salpetriere医院感染与热带病学科进修学习。

1999年01月-1999年10月,北京协和医院感染内科主治医师。

1999年10月-2004年08月,北京协和医院感染内科副主任医师

2002年07月-2010年11月,北京协和医院内科学系副主任,感染内科副主任。

2002年07月-2017年12月,北京协和医院内科学系总支书记。

2002年08月-至今,北京协和医院艾滋病诊疗中心主任。

2004年09月-至今,北京协和医院感染内科主任医师

2005年04月-至今,北京协和医学院-清华大学医学部博士生导师。

2010年11月-至今,北京协和医院感染内科主任。

2018年04月-2021年03月,清华大学医学院特聘教授。

2021年12月1日,参加中国中央电视台节目《健康之路》。

擅长领域

李太生教授擅长的领域包括:

1. 发热待查;

2. 各种感染性疾病的诊治;

3. 免疫抑制人群的诊治。

社会任职

李太生教授在社会任职方面也有丰富的经验,曾任卫生部艾滋病临床专家组副组长和卫生部艾滋病专家咨询委员会临床组副组长,中华医学会传染病与寄生虫分会常委兼艾滋病学组组长、中华医学会热带病和寄生虫分会常委。他还曾任中华医学会热带病和寄生虫分会主委、感染病学分会副主委。

另外还是《Emerging Microbes \u0026 Infections》《Journal of Clinical 病毒学》《International Journal of Medical Informatics》《AIDS Care》《Journal of Medical Virology》《Therapeutics and Clinical Risk Management》《AIDS Research and Human Retroviruses》《International Journal of STD \u0026 AIDS》《SAGE Open Medicine》《Global Journal of 麻醉学》《BMJ Case Reports》《中华内科杂志》《中华传染病杂志》《汉语词类 Medical Sciences Journal》《Clinical Intensive Care and 药品》等学术杂志审稿人;还是《艾滋病》中文版主编, 《中华内科杂志》和《中华传染病杂志》副主编。

主要成就

科研成就

1990年在国内读硕士学位期间建立了ELISA法测定血清G-CSF水平,该发现已获国家专利经国家批准用于临床发热的诊断及鉴别诊断。

1993年-1999年在法国学习期间先后在《科学》《自然医学》《柳叶刀》等杂志上发表数篇论著。于1997年首先提出了艾滋病病人的免疫功能重建的新理论。

1998年在国际上提出艾滋病抗病毒免疫重建理论,并将免疫重建理论与我国抗艾实践相结合,牵头搭建全国艾滋病治疗研究网络。开创并不断优化国产抗病毒药物方案,创建了适宜国情的艾滋病抗病毒及免疫重建模式。

1999年回国后在北京协和医院创建了临床细胞免疫实验室,建立了中国正常人的T细胞免疫功能正常值。并对中国艾滋病病人的免疫改变和免疫功能重建进行了开创性研究。回国以来,在各会议培训班做有关艾滋病的讲学报告近百次,听讲学员上万人,为国家培训了一大批防治艾滋病的骨干力量。现负责着包括欧盟美国NIH的艾滋病CIPRA项目在内的多项国际国内科研课题。

首建临床细胞免疫表型检测平台并应用于疑难危重感染病的诊治。在2003年非典疫情期间,于国际上最早报道SARS急性期T细胞计数出现显著降低,为早期识别和疫情防控提供了重要依据。在临床实践中提出的“早期、小量、短程”的激素治疗方案,大幅降低了SARS患者的死亡率及并发症。

北京协和医院感染内科李太生教授团队的研究结果表明,以中药雷公藤总苷改构研制的国家I类新药羟基雷公藤内酯醇,对于长期抗病毒治疗后免疫重建不佳的艾滋病,可有效提升其CD4+T淋巴细胞计数水平。这一研究结果在线发表于《柳叶刀—区域健康(西太平洋)》,是针对艾滋病免疫重建不全难题的一大突破。​

主持制定中国首部《艾滋病诊疗指南》,并向全国发布。又在国内率先提出艾滋病综合诊治的理念并建立综合诊治体系,报道了HIV感染者多系统疾病的发病规律,为改善感染者的长期生存质量提供技术支持

主要论文

共发表学术论文近200篇,其中在SCI收录的杂志上发表论文共40篇,被他人引用2000多次,在《科学》《自然医学》《柳叶刀》等国际权威科学杂志上发表了多篇学术论文。

(带*为通讯作者)

1、Luo L,Wang N,Yue Y,Han Y,Lv W,Liu Z,裘姓 Z,Lu H,Tang X,Zhang T,Zhao M,He Y,Shenghua H,Wang M,Li Y,Huang S,Li Y,Liu J,Tuofu Z,Routy JP, Li T*. The effects of antiretroviral therapy initiation 时间 on HIV reservoir 开本 in 汉语词类 chronically HIV infected patients:a prospective,multi-site cohort study[J]. BMC Infectious Diseases,2019,19(1).

2、Luo L,Wang H,Fan H,Xie J,Qiu Z,Li T*. The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr 病毒 disease at a Tertiary Care Hospital in Beijing. MEDICINE,97(9)(2018):e9854.

3、Luo L,Han Y,Song X,Zhu T,Zeng Y,Li T*. CD16-expressing 单核细胞 correlate with arterial stiffness in HIV-infected ART-naive men,HIV CLIN TRIALS,19(2)(2018):39-45.

4、Sang X,Chen Y,Chen W,Xie J,Meng G,Zhong J,Li T*,Lu A*. Celastrol specifically inhibits the activation of NLRP3inflammasome.Sci China Life Sci.61(3)(2018):355-357.

5、Lu W,Feng Y,Jing F,Han Y,Lyu N,Liu F,Li J,Song X,Xie J,裘姓 Z,Zhu T,Routy B,Routy JP,Li T*,Zhu B*. Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients,Front Microbiol,9(2018):1451.

6、Guo F,成姓 X,Hsieh E,Du X,Fu Q,Peng W,Li Y,Song X,Routy JP,Li T*. Prospective 等离子体 依法韦仑 concentration assessment in 汉语词类 HIV-infected adults enrolled in a large multicentre study,HIV MED,19(7)(2018):440-451.

7、Guo F,Hsieh E,Lv W,Han Y,Xie J,Li YL,Song XJ,Li TS*. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease. BMC Infect Dis,17(1)(2017):287.

8、Xie J,Hsieh E,Sun MQ,Wang HL,Lv W,Fan HW,Li TS*. Delays in HIV Diagnosis and Associated Factors among Patients Presenting with AdvancedDisease at A Tertiary Care Hospital in Beijing,China. PLOS ONE. 12(8)(2017):e0182335.

9、Du XL,Kou HJ,Fu Q,Li YL,Zhu Z,Li TS*. Steady-state 药物代谢动力学 of tenofovir disoproxil fumarate in human immunodeficiency 病毒-infected Chinese patients. Expert Rev Clin Pharmacol,10(7)(2017):783-788.

10、Li YJ,Xie J,Wang HL,Han Y,Wang ND,Thio CL,Li TS*.. Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV coinfection. 小红伞 Ther,22(6)(2017):523-527.

11、Yue YS,Wang ND,Han Y,Zhu T,Xie J,Qiu ZF,Song XJ,Li YL,Routy JP,Wang JH,Li TS*. A higher CD4/CD8 ratio correlates with an ultralow 细胞associated HIV-1 脱氧核糖核酸 level in chronically infected patients on antiretroviral therapy: a case 监察 study. BMC Infect Dis,17(1)(2017):771.

12、Wang N,Li Y,Han Y,Xie J,Li T*. HIV 序列 diversity during the early phase of infection is associated with HIV 脱氧核糖核酸 还原s during antiretroviral therapy. J Med Virol. 89(6)(2017):982-988.

13、Zhang H,Wang HL*,Zhong DR,Liu Y,Li NN,Zhang W,Xiao Y,Li TS*. Fatal Pulmonary Kaposi Sarcoma in an HIV seronegative 艾滋病 patient. Clin Respir J. 11(6)(2017):1040-1044.

14、Wang ND,Li TS*. Factors Associated with the 开本 of HIV 脱氧核糖核酸 Reservoir[J]. 汉语词类 Medical Journal,130(2)(2017):224-230.

15、Qin L,Xie J,裘姓 ZF,Cao W,Jiao Y,Jean‐Pierre Routy,and Li TS*. Aging of immune system: Immune 标记 from peripheral blood 淋巴细胞 subsets in 1068 healthy adults . AGING-US,8(5)(2016):848-859.

16、Guo FP,Li YJ,裘姓 ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS*,Routy JP. Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected Late Presenters. Chin Med J (Engl). 129(22)(2016):2683-2690.

17、Xie J,Han Y,Qiu ZF,Li YJ,Li YL,Song XJ,Wang HL,Chloe L Thio,Li TS*. Prevalence of 肝炎 B and C 病毒es in HIV-positive patients in China: a cross-sectional study. J Int 艾滋病 Soc,19:20659(2016).

18、Li YJ,Xie J,Han Y,Wang HL,Zhu T,Wang ND,Lv W,Guo FP,Qiu ZF,Li YL,DuSS,Song XJ,Chloe L Thio,Li TS*.Lamivudine monotherapy-based cART is efficacious for HBV treatment in HIV/HBV co-infection when baseline HBV 脱氧核糖核酸\u003c20,000IU/ml. J Acquir Immune DeficSyndr. 72(1)(2016): 39-45.

19、Li YJ,Xie J,Han Y,汪姓 HL,Lv W,Guo FP,Qiu ZF,Li YL,Du SS,Song XJ,Zhu T,Thio,CL,Li TS*. 组合 Antiretroviral Therapy Is Associated With Reduction in Liver 纤维化 Scores in HIV-1-Infected Subjects. MEDICINE,95(5)(2016):e2660.

20、Hsieh E,Fraenke L,Han Y,Xia W,Insogna KL,Yin MT,Zhu T,Cheng X,Li TS*. Longitudinal increase in vitamin D binding protein levels after initiation of 替诺福韦/lamivudine/依法韦仑 among individuals with HIV. 艾滋病. 30(12)(2016):1935-1942.

21、Li HP,Chang S,Han Y,壮族 D,Li L,Liu Y,Liu S,Bao Z,Zhang W,Song H,Li TS*,Li J*. The prevalence of drug 厚膜电阻 among treatment-naïve HIV-1-infected individuals in China during pre- and post-2004[J]. BMC infectious diseases,16(605)(2016).

22、Han Y,Li YJ,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Li TS*.Week 120 efficacy of 替诺福韦,lamivudine and lopinavir/r-based second-line antiretroviral therapy in treatment-experienced HIV patienSS501 PLoS One.10(3)(2015)e120705.

23、Dou HT,Xu Y,Li TS*. Application of the DiversiLab system for tracing the source of the mixed infections caused by Cryptococcus neoformans var. grubii from a patient with systemic lupus erythematosus. Mycoses. 58(3)(2015):149-159.

24、Zhang CD,Chow FC,Han Y,Xie J,Qiu Z,Guo F,Li Y,汪姓 H,Li TS*. Multicenter cohort study of 糖尿病 mellitus and impaired fasting glucose in HIV-infected patients in China. J Acquir Immune DeficSyndr. 68(3)(2015):298-303.

25、GE Y\u0026 Li TS*.May early intervention with intravenous immunoglobulin pose a potentially successful treatment for Ebola virus infection? Life Sciences58(1)(2015):108-110.

26、Li YJ,Gu LJ,Han Y,Xie J,汪姓 HL,Lv W,Song XJ,Li YL,Iwamoto,A,Ishida T,Li TS*. HIV-1 Subtype B/B ' and Baseline Drug 厚膜电阻 Mutation Are Associated With Virologic Failure: A Multicenter Cohort Study in China. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,68(3)(2015):289-297.

27、Hsieh E,Fraenkel L,Xia W,Hu YY,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*. Increased bone resorption during 替诺福韦 plus lopinavir/ritonavir therapy in 汉语词类 individuals with HIV. Osteoporos Int.26(3)(2015):1035-1044.

28、Gu LJ,Han Y,Li Y,Zhu T,Song X,Huang Y,Yang F,Guan S,Xie J,Gohda J,Hosoya N,Kawana-Tachikawa A,Liu W,Gao GF,Iwamoto A,Li TS*,Ishida T. Emergence of Lamivudine-Resistant HBV during Antiretroviral Therapy Including Lamivudine for Patients Coinfected with HIV and HBV in China. PLoS One. 10(8)(2015) e0134539.

29、Li TS*,Xie J,Li Y,Routy JP,Li Y,Han Y,Qiu Z,Lv W,Song X,Sun M,Zhang X,汪姓 F,Jiang H. Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety. HIV Clin Trials. 16(2)(2015):49-56.

30、Fan HW,Guo FP,Li YJ,Li N,Li TS*. Prevalence of thrombocytopenia among 汉语词类 adult antiretroviral-naïveHIV-positive patients. Chin Med J (Engl). 128(4)(2015):459-464.

31、Li YJ,Han Y,Xie J,Gu L,Li W,汪姓 H,Lv W,Song X,Li Y,Routy JP,Ishida T,Iwamoto A,Li TS*; CACT0810 基团 CRF01_AE subtype is associated with X4 向性 and fast HIV progression in 汉语词类 patients infected through sexual transmission. 艾滋病.28(4)(2014):521-530.

32、Guo FP,Liu Y,Li Y,Fan H,Li TS*. Disseminated Mycobacterium avium 情结 infection manifested as Brown-Séquard 综合征 in an HIV-infected patient. Chin Med J (Engl). 127(4)(2014):799.

33、Luo L,Zeng Y,Li TS*,Lv W,汪姓 HL,Guo FP,Han Y,Xie J,Qiu ZF,Li YL,Song XJ,Zhu T,Zhang XY,Li L,Ye YC,He Y,Lu HZ,Huang AQ,Tang XP,Wang H,Zhang T,Gao GJ,Lei JK,Wu XH,Sun YT,Bai JS,Li KL. . Prospective Echocardiographic Assessment of Cardiac Structure and Function in 汉语词类 Persons Living With HIV. Clinical Infectious Diseases,58(10)(2014):1459-1466.

34、Li TS*,Guo F,Li Y,Zhang C,Han Y,Lye W,He Y,Lu H,Xie J,Huang A,Li Y,Tang X,Wang H,Zhang T,Gao G,Lei J,Zhang X,Wu X,Sun Y,Bai J,Luo L,Wang H. An antiretroviral regimen containing 6 months of 司他夫定 followed by long-term 齐多夫定 for first-line HIV therapy is optimal in 资源limited settings: a prospective,multicenter study in China. Chin Med J (Engl). 127(1)(2014):59-65.

35、Cao W,QiuZF,Zhu T,Li Y,Han Y,Li TS*.CD8+ T cell responses specific for hepatitis B 病毒 core protein in patients with chronic hepatitis B virus infection. Journal of Clinical 病毒学61(2014): 40-46.

36、Hsieh E,Fraenkel L,Bradley EH,Xia W,Insogna KL,Cui Q,Li K,Li TS*.骨质疏松症 knowledge,self-efficacy,and health beliefs among 汉语词类 individuals with HIV. 弓形 Osteoporos. 9(1)(2014):201.

37、Ge Y,Li TS*,Liu ZY,Liu M,Guan H,Chen L,Tian Y,壮族 Q. A rare cause of fever of unknown origin-cervical spinal cord lesion. Chin Med J (Engl).127(19)(2014):3517-3518.

38、Hsieh E,Fraenkel L,Bradley E,Xia W,Qu C,Ling L,Insogna K,Li TS*. 骨质疏松症 knowledge,self-efficacy,and health beliefs among 汉语词类 men and women with HIV. Ann Rheum Dis. 73 Suppl 1(2014):A62-3.

39、Hsieh E,Fraenkel L,Xia W,Hu Y,Han Y,Insogna K,Yin MT,Xie J,Zhu T,Li TS*.Increased bone turnover after switch to 替诺福韦 + lopinavir/ritonavir in 汉语词类 HIV + patients. Ann Rheum Dis. 73 Suppl 1(2014):A62.

40、Kou HJ,Du X,Li Y,Xie J,Qiu Z,Ye M,Fu Q,Han Y,Zhu Z,Li TS*,Comparison of nevirapine 等离子体 concentrations between in and steady-state periods in 汉语词类 HIV-infected patients. PLoS One. 8(1)(2013):e52950.

41、Cao Y,Gong M,Han Y,Xie J,Li X,Zhang L,Li Y,Song X,Zhu T,Li TS*. Prevalence and risk factors for chronic 肾脏 disease among HIV-infected antiretroviral therapy-naïve patients in 汉语词类 mainland:A multicenter cross-sectional study. Nephrology (Carlton). 18(4)(2013):307-312.

42、Zhang C,Wang W,Zhou M,Han H,Xie J,Qiu Z,Guo F,Li Y,Wang H,Ghanem KG,Li TS*. The Interaction of CD4 T-Cell 计数 and Nevirapine Hepatotoxicity in China: A Change in National Treatment Guidelines May Be Warranted. J Acquir Immune Defic Syndr.62(2013):540–545.

43、Cao Y,Han Y,Xie J,Cui Q,Zhang L,Li Y,Li Y,Song X,Zhu T,Li TS*. Impact of a 替诺福韦 disoproxil fumarate plus ritonavir-boosted Prorese inhibitor-based regimen on renal function in HIV-infected Individuals:a prospective,multicenter study. BMC Infect Dis.13(2013):301.

44、Zhang LX,Su Y,Hsieh E,Xia W,Xie J,Han Y,Cao Y,Li Y,Song X,Zhu T,Li TS*,Yu W. Bone turnover and bone mineral 密度 in HIV-1 infected 汉语词类 taking highly active antiretroviral therapy-a prospective observational study. BMC MusculoskeletDisord. 14(2013):224.

45、Wang HL,Ghanem KG,Wang P,Yang S,Li TS*. Listeriosis at a tertiary care hospital in beijing,china: High prevalence of non-clustered healthcare-associated cases among adult patients. Clin Infect Dis.56(5)(2013):666-676.

46、Kou H,Du X,Li Y,Fu Q,Zhu Z,Li TS*.Quantification of tenofovir in human 等离子体 by 固体phase extraction and high-performance 羧基液体丁腈橡胶 chromatography coupled with UV detection. Ther Drug Monit. 34(5)(2012):593-598.

47、Wang H,Li Y,Zhang C,Han Y,Zhang X,Zhu T,Li TS*. Immunological and virological responses to cART in HIV/HBV co-infected patients from a multicenter cohort. 艾滋病. 26(14)(2012):1755-1763.

48、Kou HJ,Ye M,Fu Q,Han Y,Du X,Xie J,Zhu Z,Li TS*. Simultaneous quantification of lopinavir and ritonavir in human 等离子体 by high performance 羧基液体丁腈橡胶 chromatography coupled with UV detection. SciChina Life Sci. 55(4)(2012):321-327.

49、Li YJ,Wang HL,Li TS*. 肝炎 B virus/human immunodeficiency virus coinfection: Interaction among human immunodeficiency virus infection,chronic hepatitis B virus infection,and 宿主 免疫力 Chin Med J (Engl). 125(13)(2012):2371-2377.

50、Li,CG; Yang,PH; Sun,Y; Li,TS; Wang,C; Wang,Z; Zou,Z; Yan,YW; Wang,W; Wang,C; Chen,ZW; Xing,L; Tang,C; Ju,XW; Guo,F; Deng,JJ; Zhao,Y; Yang,P; Tang,J; Wang,HL; Zhao,ZP; Yin,ZN; Cao,B; Wang,XL; Jiang,CY. 2012. IL-17 response mediates acute lung injury induced by the 2009 pandemic 流行性感冒 A (H1N1) 病毒. CELL RESEARCH,22(3):528-538.

51、Liu LF,Wang L,Fu Q,Zhu Z,Xie J,Han Y,Liu ZY,Ye M,Li TS*. Steady-state 药物代谢动力学 of 齐多夫定 in ChineseHIV-infected patients. Chin Med J (Engl). 125(11)(2012):1931-1935.

52、Li TS*,Wu N.CD31(+) Cell Percentage Correlation With Speed of CD4(+) T-Cell 计数 Recovery in HIV-Infected Adults Is Reversed in Children:Higher Thymic Output May Be Responsible Reply. CLIN INFECT DIS .55(2) (2012):307-309.

53、Cao W,Qiu ZF,Li TS*. 纬线 decline of CD8+CD38+ lymphocytes and viremia in treated 肝炎 B patients. World J Gastroenterol. 17(17)(2011):2191-2198.

54、Liu LF,Xie J,Sun J,Han Y,Zhang C,Fan H,Liu Z,Qiu Z,He Y,Li TS*. Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory 综合征 正冠状病毒亚科 components and neutralizing activities in recovered patients[J]. Scandinavian journal of infectious diseases,43(6-7)(2011):515-521.

55、Li TS*,Wu N,Dai Y,Qiu Z,Han Y,Xie J,Zhu T,Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy. Clin Infect Dis. 53(9)(2011):944-51.

56、Han Y,Wu N,Zhu WJ,Li YL,左姓 LY,Ye JJ,Qiu ZF,Xie J and Li TS*.Detection of HIV-1 viruses in tears of patients evenunder long-term HAART,AIDS,25(15)(2011):1925-1927.

57、Wang J,Kou H,Fu Q,Han Y,Qiu Z,Zuo L,Li Y,Zhu Z,Ye M,Ma Q,Li TS*.Nevirapine 等离子体 concentrations are associated with virologic response and hepatotoxicity in 汉语词类 patients with HIV infection. PLoS One. 6(10)(2011):e26739.

58、Luo L,Li TS*.Overviewof antiretroviral treatment in china:advancement and challenges Chinese Medical Journal;124(3)(2011):440-444.

59、Ye M,Wang L,Fu Q,Zhu Z,Li P,Li TS*. Steady-State 药物代谢动力学 of Lamivudine Once-Daily Versus TWICEDaily Dosing in 汉语词类 HIV-Infected Patients. HIV Clin Trials. 11(4)(2010):230-237.

60、Ye Y,Zeng Y,Li X,Zhang S,Fang Q,Luo L,Qiu Z,Han Y,Li TS*. Human immunodeficiency 病毒 Infection: An Independent Risk Factor of Peripheral Arterial Disease. J Acquir Immune DeficSyndr. 53(2)(2010):276-278.

61、Guo FP,Lv W,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of Hepatitis C Virus Coinfection on HAART in HIV-Infected Individuals: Multicentric Observation Cohort. J艾滋病-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES,54(2)(2010):137-142.

62、Luo L,Ye Y,Guo F,左姓 L,Li Y,Qiu Z,Han Y,Li L,Zeng Y*,Li TS*. Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China. Int J STD 艾滋病;21(12)(2010):814-818.

63、Zeng Y,Ye Yc,Luo L,Qiu ZF,Han Y,Li XM,Fang QA,Zang SY and Li TS*.Premature atherosclerosis in patients with acquired immunodeficiency 综合征 Chinese Medical Journal,123(23)(2010):3396-3399.

64、Cao ZL,Liu LF,Du LY,Zhang C,Jiang S,Li TS*,He YX*. Potent and persistent antibody responses against the receptor-binding 论域 of 严重急性呼吸综合征CoV spike protein in recovered patients[J]. Virology journal,7(2010):299.

65、Xie J,Jiao Y,Qiu Z,Li Q,Li TS*. Significant elevation of B cells at acute stage in enterovirus 71-infected children with central nervous system involvement. Scand J Infect Dis. 42(11-12)(2010):931-935.

66、Liu J,Wu P,Gao F,Qi JX,Kawana-Tachikawa,A,Xie J,Vavricka,CJ, Iwamoto,A,Li TS*,Gao GF. Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-淋巴细胞 Epitope Stabilized by Intrachain Bonds from Severe Acute Respiratory 综合征 正冠状病毒亚科 Nucleocapsid Protein. JOURNAL OF VIROLOGY. 84(22)(2010):11849-11857.

67、Jiao Y,裘姓 ZF,Xie J,Li DJ,Li TS*. Reference ranges and agerelated changes of peripheral blood 淋巴细胞 subsets in 汉语词类 healthy adults. Sci China C Life Sci,52(7)(2009):643-650.

68、Liu ZY,Guo FP,Han Y,Qiu ZF,Zuo LY,Li YL,Li TS*. Impact of baseline CD4(+) T cell counts on the efficacy of nevirapine-based highly active antiretroviral therapy in 汉语词类 HIV/AIDS patients: a prospective,multicentric study. Chin Med J (Engl). 122(20)(2009):2497-2502.

69、Luo L,Zhang L,Tao MM,Qiu ZF,Xie J,Han Y,Li M,Li TS*. Adiponectin and Leptin Levels in Chinese Patients with HIV-Related Lipodystrophy: A 30-Month Prospective Study. 艾滋病 Res Hum Retroviruses. 25(12)(2009):1265-1272.

70、Zhang HW,Qiu ZF,Jiao Y,Wang AX,Li TS*. HIV-specific CD8(+) T cell responses to HXB2 Gag and Nef 多肽 pools in 汉语词类 HIV/AIDS patients. SCIENCE IN CHINA SERIES C-LIFE SCIENCES. 52(9)(2009):841-846.

71、Luo L,Li TS*.Idiopathic CD4 Lymphocytopenia and opportunistic infection an update.FEMSImmunol Med Microbiol.54(2008):283-289.

72、Li TS*,Dai Y,Kuang JQ,Jiang JM,Han Y,Qiu ZF,Xie J,Zu,LY,Li YL. Three Generic Nevirapine-Based Antiretroviral Treatments in 汉语词类 HIV/AIDS Patients: Multicentric Observation Cohort. PLOS ONE. 3(12)(2008):e3918.

73、Qing ML,Li TS*,Han Y,Qiu ZF,Jiao Y. Accelerating effect of human leukocyte 抗原Bw6 homozygosity on disease progression in 汉语词类 HIV-1 - Infected patients. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 41(2)(2006):137-139.

74、Jiao Y, Xie J,Li TS*,Han Y,Qiu ZF,Zuo LY,Wang AX. Correlation between Gag-specific CD8 T-cell responses,viral load and CD4 计数 in HIV-1 infection is dependent on disease status. J Acquir Immune DeficSyndr,42(3)(2006):263-268.

75、Jiao Y,Li TS*,Xie J,Han Y,Qiu ZF,左姓 LY,Thomas Mourez,Wang AX. Association between Nef-Specific CD8+ T-Cell Responses and disease progression in HIV-1 Subtype B Infection. 汉语词类 Medical Journal,119(19)(2006):1609-1615.

76、Wang AX,Wang FS,Wang QY,Jian W,Feng TJ,Lu HZ,Sun HQ,Sun YT,Ye HH,Li TS*,Li XW,Liu ZY,Xing YL,Yun H,Ning W,Hao W,Wu NP,Zhang FJ,Zhou ZQ,Gong EC,Zhao HX,Min Z,Tang XP,Xu LZ,Xu XY,Cao YZ,Kang LY,Yan J,Cai WP,Fan QB,Pan XZ. Guidelines for diagnosis and treatment of HIV/AIDS in China (2005). 汉语词类 MEDICAL JOURNAL. 119(19)(2006): 1589-1608.

77、Dai Y,QiuZF,Li TS*,Han Y,左姓 LY,Xie J,Ma XJ,Liu ZY,Wang AX. Clinical outcomes and immune reconstitution in 103 advanced AIDS patients undergoing 12-month highly active antiretroviral therapy. 汉语词类 Medical Journal,119(20)(2006):1677-1682.

78、Li TS*,Xie J,He Y,Fan H,Baril L,Qiu Z,Han Y,Xu W,Zhang W,You H,左姓 Y,Fang Q,Yu J,Chen Z,Zhang L. Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with 严重急性呼吸综合征 正冠状病毒亚科[J]. PloS one,1(2006):e241.

79、Li TS*,Qiu ZF,Zhang LQ,Han Y,He W,Liu ZY,Ma XJ,Fan HW,Lu W,Xie J,Wang HL,Deng GH,Wang A. Significant changes of peripheral T 淋巴细胞 subsets in patients with severe acute respiratory 综合征 JOURNAL OF INFECTIOUS DISEASES. 189(4)(2004):648-651.

80、LI TS*,Qiu ZF,Han Y,Wang Z,Fan HW,Lu W,Xie J,Ma XJ and Wang AX. Rapid loss of both CD4~+ and CD8~+ T 淋巴细胞 subsets during the acute phase of severe acute respiratory 综合征[J]. 汉语词类 medicaljournal,116(7)(2003):985-987.

81、Li TS; Tubiana R; Fillet AM; Autran B; Katlama,C. 阳性 result of 巨细胞病毒 blood culture with restoration of CD4(+) T-cell reactivity to cytomegalovirus after HAART in an HIV-1-infected patient.JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES.20(5)(1999):514-515.

82、Gorochov,G; Neumann,AU; Kereveur,A; Parizot,C; Li,TS; Katlama,C; Karmochkine,M; Raguin,G; Autran,B; Debre,P. 1998. Perturbation of CD4(+) and CD8(+) T-cell repertoires during progression to AIDS and regulation of the CD4(+) repertoire during antiviral therapy. NATURE MEDICINE. 4(2):215-221.

83、Li TS;Tubiana,R; Katlama,C; Calvez,V; AitMohand,H; Autran,B. Long-lasting recovery in CD4+ T cell function minors viral load reduction after highly active anti-retroviral therapy in patients with advanced HIV disease. Lancet. 351(1998):1682-1686.

84、Autran,B; Carcelain,G; Li,TS; Blanc,C; Mathez,D; Tubiana,R; Katlama,C; Debre,P; Leibowitch,J. 1997. Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease. SCIENCE.277(5322):112-116.

著作译作

1. 李太生共同主编,《国家卫生和计划生育住院医师规范化教材内科学感染科分册》,人民卫生出版社出版,2016年,北京。

2. 李太生主编,《中华医学百科全书》感染性疾病学卷,中国协和医科大学出版社,2013年,北京。

3. 李太生,艾滋病的免疫应答和免疫重建研究进展,第496-511页,《中国艾滋病流行与控制》,王陇德主编,北京出版社,2006,北京。

4. 李太生,艾滋病,第175-191页,肺孢子菌病,不明原因发热的诊断思维,418-421页,558-563页,免疫缺陷病患者的感染,586-599页,《感染病学》,李兰娟等主编,人民卫生出版社,2005,北京。

获得荣誉

法国优秀外国医师奖(Vctoria Hugo奖)(1999年)

中华医学会医药卫生科技进步二等奖(2002年)

北京市科技进步三等奖(2003年)

北京市首都《五一》劳动奖章获得者(2003年)

全国抗击严重急性呼吸综合征优秀科技工作者(2003年)

全国留学回国人员先进个人代表(2003年)

全国五一劳动奖章(2004年)

第八届全国青年科技奖获得者(2004年)

国家级新世纪“百千万人才工程”(2006年)

中华医学会医药卫生科技进步三等奖(2007年)

国务院特殊津贴获得者(2008年)

北京市科技进步二等奖(2009年)

中国医学科学院“群众心目中的优秀党员”(2010年)

中国医学科学院“协和学者特聘教授”(2010年)

华夏医学科技奖一等奖(2011年)

中华预防医学会科学技术二等奖(2011年)

北京市科学技术奖二等奖(2011年)

当选首批国家高层次人才特殊支持计划科技创新领军人才(2014年)

中华医学科技奖二等奖(2015年)

法国国家医学科学院“塞维雅”奖(2016年)

第十七届吴阶平保罗·杨森医学药学奖(2016年)

吴阶平医药创新奖(2018年)

入围北京市2020年全国劳动模范和先进工作者推荐人选(2020年)

人物事件

2020年1月21日,新冠肺炎被正式列入乙类传染病,按甲类传染病预防。北京协和医院感染内科主任李太生领衔30位专家拟定了《北京北京协和医院关于“新型冠状病毒感染的肺炎”诊疗建议方案》,前瞻性地提出可考虑应用免疫球蛋白以及康复期病人血浆治疗的方法,为后期实际诊疗提供了参考方向。

疫情暴发之初,李太生就报名支援武汉市,2月7日,李太生,带领协和医院第二批医疗队飞抵武汉,与第一批医疗队共同接管华中科技大学同济医学院附属同济医院中法新城院区C9西病区ICU。

2020年4月15日,北京协和医院援鄂医疗队最后一批撤离,但李太生和5名同事却留了下来,继续救治重症病人。

科普宣传

李太生教授积极参与科普宣传工作,曾在《养生堂》《职场健康课》《人民网》等进行科普宣传。

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